« Previous
Next »
Journal of Reproductive Immunology
Volume 87, Issue 1
, Pages 1-13
, December 2010
Utilising T cell receptor transgenic mice to define mechanisms of maternal T cell tolerance in pregnancy
References
- . The effects of apoptotic, deported human placental trophoblast on macrophages: possible consequences for pregnancy. J. Reprod. Immunol. 2006;72:33–45
- . The changing maternal “self” hypothesis: a mechanism for maternal tolerance of the fetus. Placenta. 2007;28:378–382
- . Regulatory T cells mediate maternal tolerance to the fetus. Nat. Immunol. 2004;5:266–271
- . The degree of CD8 dependence of cytolytic T cell precursors is determined by the nature of the T cell receptor (TCR) and influences negative selection in TCR-transgenic mice. Eur. J. Immunol. 1994;24:1572–1577
- . Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific. J. Reprod. Immunol. 2004;61:67–77
- . Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8(+) T cell response to infection. Immunity. 2007;26:827–841
- . Host responses to intra-uterine tissue, cellular and fetal allografts. J. Reprod. Fertil. Suppl. 1974;21:59–88
- . Dendritic cells: a family portrait at mid-gestation. Immunology. 2009;126:565–578
- . Estimating the precursor frequency of naive antigen-specific CD8 T cells. J. Exp. Med. 2002;195:657–664
- . Lineage, maturity, and phenotype of uterine murine dendritic cells throughout gestation indicate a protective role in maintaining pregnancy. Biol. Reprod. 2004;70:1018–1023
- . Fas/Fas ligand interaction at the placental interface is not required for the success of allogeneic pregnancy in anti-paternal mhc preimmunized mice. Am. J. Reprod. Immunol. 2001;45:108–115
- . Localization of H-2 antigens on mouse trophoblast cells. J. Exp. Med. 1979;149:1238–1253
- . Tolerance mechanisms in pregnancy: a reappraisal of the role of class I paternal MHC antigens. Am. J. Reprod. Immunol. 2010;63:93–103
- . Dendritic cell entrapment within the pregnant uterus inhibits immune surveillance of the maternal/fetal interface in mice. J. Clin. Invest. 2009;119:2062–2073
- . Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus. J. Clin. Invest. 2007;117:1399–1411
- . Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 2000;192:1027–1034
- . Fas ligand-induced apoptosis as a mechanism of immune privilege. Science. 1995;270:1189–1192
- . CD95-induced apoptosis of lymphocytes in an immune privileged site induces immunological tolerance. Immunity. 1996;5:7–16
- . Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment?. Hum. Reprod. Update. 2009;15:517–535
- . A critical role for the programmed death ligand 1 in fetomaternal tolerance. J. Exp. Med. 2005;202:231–237
- . Gamete and zygote transport. In: Knobil E, Neill JD editor. The Physiology of Reproduction. New York: Raven Press; 1994;p. 123–168
- . Naive and memory CD4+ T cell survival controlled by clonal abundance. Science. 2006;312:114–116
- . Cross-presentation, dendritic cells, tolerance and immunity. Annu. Rev. Immunol. 2001;19:47–64
- . Fas ligand is positioned in mouse uterus and placenta to prevent trafficking of activated leukocytes between the mother and the conceptus. J. Immunol. 1997;158:4122–4128
- . Apoptosis in the trophoblast—role of apoptosis in placental morphogenesis. J. Soc. Gynecol. Investig. 2004;11:353–362
- . Multiparity induces priming to male-specific minor histocompatibility antigen, hy, in mice and humans. Blood. 2003;102:388–393
- . Multiple mechanisms of peripheral T cell tolerance to the fetal “allograft”. J. Immunol. 1998;160:3086–3090
- . Semen activates the female immune response during early pregnancy in mice. Immunology. 2004;112:290–300
- . In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cell-associated antigens. Immunity. 2002;17:211–220
- . Pregnancy induces a fetal antigen-specific maternal T regulatory cell response that contributes to tolerance. Proc. Natl. Acad. Sci. U.S.A. 2010;107:9299–9304
- . Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity. 1994;1:327–339
- . Quantification of repertoire diversity of influenza-specific epitopes with predominant public or private tcr usage. J. Immunol. 2006;177:6705–6712
- . Recombinant human follicle-stimulating hormone alters maternal ovarian hormone concentrations and the uterus and perturbs fetal development in mice. Am. J. Physiol. Endocrinol. Metab. 2006;291:E761–E770
- . Natural history of fetal cell microchimerism during and following murine pregnancy. J. Reprod. Immunol. 2005;66:1–12
- . Correlation between oral sex and a low incidence of preeclampsia: a role for soluble hla in seminal fluid?. J. Reprod. Immunol. 2000;46:155–166
- . Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8+ T cells. J. Exp. Med. 1997;186:239–245
- . The peripheral deletion of autoreactive CD8+ T cells induced by cross-presentation of self-antigens involves signaling through CD95 (Fas, Apo-1). J. Exp. Med. 1998;188:415–420
- . CXCL12 enhances exogenous CD4+ CD25+ T cell migration and prevents embryo loss in non-obese diabetic mice. Fertil. Steril. 2009;91:2687–2696
- . Induction of peripheral CD4+ T-cell tolerance and CD8+ T-cell cross-tolerance by dendritic cells. Eur. J. Immunol. 2009;39(September(9)):2325–2330
- . HLA-G transgenic mice. J. Reprod. Immunol. 1999;43:253–261
- . Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancy. Nat. Immunol. 2001;2:64–68
- . Cross-presentation of male seminal fluid antigens elicits T cell activation to initiate the female immune response to pregnancy. J. Immunol. 2009;182:8080–8093
- . Dendritic cells in immunity and tolerance—do they display opposite functions?. Immunity. 2003;19:5–8
- . Dendritic cell regulation of Th1-Th2 development. Nat. Immunol. 2000;1:199–205
- . Prevention of allogeneic fetal rejection by tryptophan catabolism. Science. 1998;281:1191–1193
- . B7 family molecules are favorably positioned at the human maternal–fetal interface. Biol. Reprod. 2003;68:1496–1504
- . Localization of fetal major histocompatibility complex antigens and maternal leukocytes in murine placenta. Implications for maternal–fetal immunological relationship. Lab. Invest. 1989;61:27–36
- . Seminal plasma and male factor signalling in the female reproductive tract. Cell Tissue Res. 2005;322:43–52
- . Cytokine-leukocye network and the establishment of pregnancy. Am. J. Reprod. Immunol. 1997;37:438–442
- . Seminal fluid drives expansion of the CD4+ CD25+ T regulatory cell pool and induces tolerance to paternal alloantigens in mice. Biol. Reprod. 2009;80:1036–1045
- . The role of semen in induction of maternal immune tolerance to pregnancy. Semin. Immunol. 2001;13:243–254
- . Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance. J. Exp. Med. 1995;181:993–1003
- . Peripheral selection of the T cell repertoire. Science. 1991;251:1225–1228
- . Maternal-fetal tolerance is maintained despite transgene-driven trophoblast expression of MHC class I and defects in Fas and its ligand. Eur. J. Immunol. 1998;28:3479–3487
- . Paternal antigen-bearing cells transferred during insemination do not stimulate anti-paternal CD8+ T cells: role of estradiol in locally inhibiting CD8+ T cell responses. J. Immunol. 2006;177:7567–7578
- . Estradiol-induced vaginal mucus inhibits antigen penetration and CD8(+) T cell priming in response to intravaginal immunization. Vaccine. 2009;27:2342–2349
- . Seminal plasma differentially regulates inflammatory cytokine gene expression in human cervical and vaginal epithelial cells. Mol. Hum. Reprod. 2007;13:491–501
- . Regulatory T cells are necessary for implantation and maintenance of early pregnancy but not late pregnancy in allogeneic mice. J. Reprod. Immunol. 2010;85:121–129
- . Tolerogenic dendritic cells. Annu. Rev. Immunol. 2003;21:685–711
- . Optimization of tcr transgenic T cells for in vivo tracking of immune responses. Immunol. Cell Biol. 2007;85:394–396
- . T cell awareness of paternal alloantigens during pregnancy. Science. 1995;270:30–31
- . Maternal pd-1 regulates accumulation of fetal antigen-specific CD8+ T cells in pregnancy. J. Reprod. Immunol. 2009;80:12–21
- . Seminal transforming growth factor beta1 stimulates granulocyte-macrophage colony-stimulating factor production and inflammatory cell recruitment in the murine uterus. Biol. Reprod. 1998;58:1217–1225
- . Mother's little helpers: mechanisms of maternal–fetal tolerance. Nat. Immunol. 2006;7:241–246
- . CD28 costimulation is required for in vivo induction of peripheral tolerance in CD8 T cells. J. Exp. Med. 2003;197:19–26
- . Fetal expression of fas ligand is necessary and sufficient for induction of CD8 T cell tolerance to the fetal antigen h-y during pregnancy. J. Immunol. 2005;174:4657–4661
- . Antigen-presenting cells in the female reproductive tract: influence of sex hormones on antigen presentation in the vagina. Immunology. 1995;84:505–508
- . Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+ CD25+ T regulatory cells prevents fetal rejection in a murine abortion model. Am. J. Pathol. 2005;166:811–822
- . Expanded cohorts of maternal CD8+ T-cells specific for paternal MHC class I accumulate during pregnancy. J. Reprod. Immunol. 1998;40:47–62
- . On cross-priming of MHC class I-specific CTL: rule or exception?. Eur. J. Immunol. 2002;32:2385–2392
☆ This work was supported by a Program Grant and Fellowship from the National Health and Medical Research Council, Australia (SAR).
PII: S0165-0378(10)00103-8
doi: 10.1016/j.jri.2010.05.007
« Previous
Next »
Journal of Reproductive Immunology
Volume 87, Issue 1
, Pages 1-13
, December 2010
