Journal of Reproductive Immunology
Volume 87, Issue 1 , Pages 45-51 , December 2010

Developmental ontogeny of autoantigens associated with localized autoimmunity in murine testis and epididymis

Received 26 February 2010 ,Revised 28 April 2010 ,Accepted 24 May 2010.

References 

  1. Alexander NJ. Immunologic and morphologic effects of vasectomy in the rhesus monkey. Fed. Proc. 1975;34:1692–1697
  2. Alexander NJ, Anderson DJ. Antisperm antibody titres, immune complex deposition and immunocompetence in long-term vasectomized mice. Clin. Exp. Immunol. 1981;43:99–108
  3. Aoki A, Fawcett DW. Impermeability of Sertoli cell junctions to prolonged exposure to peroxidase. Andrologia. 1975;7:63–76
  4. Dym M, Fawcett DW. The blood–testis barrier in the rat and the physiological compartmentation of the seminiferous epithelia. Biol. Reprod. 1970;3:308–326
  5. Isahakia M, Alexander NJ. Vesectomy-induced autoimmunity: antisperm and antinuclear autoimmune monoclonal antibodies. Am. J. Reprod. Immunol. 1984;5:117–124
  6. Itoh M, Hiramine C, Hojo K. A new murine model of autoimmune orchitis induced by immunization with viable syngeneic testicular germ cells alone. I: Immunological and histological studies. Clin. Exp. Immunol. 1991;83:137–142
  7. Itoh M, De-Rooij DG, Takeuchi Y. Mode of inflammatory cell infiltration in testes of mice injected with syngeneic testicular germ cells without adjuvant. J. Anat. 1995;187(3):671–679
  8. Itoh M, Ueno M, Li XQ, Satriotomo I, Takeuchi Y. Topographical uptake of blood–borne horseradish peroxidase (HRP) in the murine testis at the light microscopic level. Int. J. Androl. 1998;21:74–80
  9. Kojima A, Spencer CA. Genetic susceptibility to testicular autoimmunity: comparison between postthymectomy and postvasectomy models in mice. Biol. Reprod. 1983;29:195–205
  10. Kosuda LL, Bigazzi PE. Animal models of testis autoimmunity. In:  Bigazzi PE editors. Immunology of the Male Reproductive System. New York: Marcel Decker Inc.; 1987;p. 253–353
  11. Qu N, Terayama H, Naito M, Ogawa Y, Hirai S, Kitaoka M, et al. Caput epididymitis but not orchitis was induced by vasectomy in a murine model of experimental autoimmune orchitis. Reproduction. 2008;135:859–866
  12. Robaire B, Hermo L. Efferent ducts, epididymis, and vas deferens: structure, functions, and their regulation. In:  Knobil E,  Neill J editor. The Physiology of Reproduction. New York: Raven Press; 1988;p. 999–1080
  13. Rose NR, Lucas PL. Immunologic consequences of vasectomy: II. Two-year summary of a prospective study. In:  Lepow IH,  Crozier R editor. Vasectomy: Immunologic and Pathophysiologic Effects in Animals and Man. New York: Academic Press; 1979;p. 533–573
  14. Sato K, Hirokawa K, Hatakeyama S. Experimental allergic orchitis in mice. Histopathological and immunological studies. Virchows Arch. [Pathol. Anat.]. 1981;392:147–158
  15. Taguchi O, Nishizuka Y. Experimental autoimmune orchitis after neonatal thymectomy in the mouse. Clin. Exp. Immunol. 1981;46:425–434
  16. Tung KSK. Autoimmunity of the testis. In:  Dhindsa DH,  Schumacher GF editor. Immunological Aspects of Infertility and Fertility Regulation. New York: Elsevier North-Holland Press; 1980;p. 33–91
  17. Tung KSK, Yule TD, Mahi-Brown CA, Listrom MB. Distribution of histopathology and Ia positive cells in actively induced and passively transferred experimental autoimmune orchitis. J. Immunol. 1987;138:752–759
  18. Turner TT. On the epididymis and its role in the development of the fertile ejaculate. J. Androl. 1995;16:292–298
  19. Yokochi T, Ikeda H, Inoue Y, Kimura Y, Ito H, Fujii Y, et al. Characterization of autoantigens relevant to experimental autoimmune orchitis (EAO) in mice immunized with a mixture of a syngeneic testis homogenate and Klebsiella O3 lipopolysaccharide. Am. J. Reprod. Immunol. 1990;22:42–48
  20. Yule TD, Montoya GD, Russelli LD, Williams TM, Tung KSK. Autoantigenic germ cells exist outside the blood–testis barrier. J. Immunol. 1988;141:1161–1167

PII: S0165-0378(10)00100-2

doi: 10.1016/j.jri.2010.05.005

Journal of Reproductive Immunology
Volume 87, Issue 1 , Pages 45-51 , December 2010