Journal of Reproductive Immunology
Volume 85, Issue 1 , Pages 81-85 , May 2010

Antibody-mediated protection and the mucosal immune system of the genital tract: relevance to vaccine design

  • Jiri Mestecky

      Affiliations

    • Department of Microbiology, University of Alabama at Birmingham, USA
    • Department of Medicine, University of Alabama at Birmingham, USA
    • Mucosal HIV and Immunobiology Center, University of Alabama at Birmingham, USA
    • Department of Microbiology and Immunology, School of Medicine, Charles University, Prague, Czech Republic
    • Corresponding Author InformationCorresponding author at: University of Alabama at Birmingham, 845 19th Street South, Box 1, Birmingham, AL 35294-2170, USA. Tel.: +1 205 934 2225; fax: +1 205 934 3894.
  • ,
  • Milan Raska

      Affiliations

    • Department of Microbiology, University of Alabama at Birmingham, USA
    • Department of Immunology, Palacky University, Olomouc, Czech Republic
  • ,
  • Jan Novak

      Affiliations

    • Department of Microbiology, University of Alabama at Birmingham, USA
    • Mucosal HIV and Immunobiology Center, University of Alabama at Birmingham, USA
  • ,
  • Rashada C. Alexander

      Affiliations

    • Department of Microbiology, University of Alabama at Birmingham, USA
  • ,
  • Zina Moldoveanu

      Affiliations

    • Department of Microbiology, University of Alabama at Birmingham, USA
    • Mucosal HIV and Immunobiology Center, University of Alabama at Birmingham, USA

Received 4 September 2009 ,Revised 5 February 2010 ,Accepted 11 February 2010.

References 

  1. Anderson DJ, Pudney J. Human male genital tract immunity and experimental models. In: Mestecky , et al. editor. Mucosal Immunology. 3rd ed.. Amsterdam: Elsevier/Academic Press; 2005;p. 1647–1659
  2. Baba TW, Liska V, Hofmann-Lehmann R, Vlasak J, Xu W, Ayehunie S, et al. Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection. Nat. Med. 2000;6:200–206
  3. Boyaka PN, McGhee JR, Czerkinsky C, Mestecky J. Mucosal vaccines: an overview. In:  Mestecky J, et al. editor. Mucosal Immunology. 3rd ed.. Amsterdam: Elsevier/Academic Press; 2005;p. 855–873
  4. Combe E, Pirman T, Stekar J, Houlier ML, Mirand PP. Differential effect of lentil feeding on proteosynthesis rates in the large intestine, liver and muscle of rats. J. Nutr. Biochem. 2004;15:12–17
  5. Corthesy B. Roundtrip ticket for secretory IgA: role in mucosal homeostasis?. J. Immunol. 2007;178:27–32
  6. Cuburu N, Kweon MN, Song JH, Hervouet C, Luci C, Sun JB, et al. Sublingual immunization induces broad-based systemic and mucosal immune responses in mice. Vaccine. 2007;25:8598–8610
  7. Fujihashi K, Koga T, van Ginkel FW, Hagiwara Y, McGhee JR. A dilemma for mucosal vaccination: efficacy versus toxicity using enterotoxin-based adjuvants. Vaccine. 2002;20:2431–2438
  8. Jackson S, Mestecky J, Moldoveanu Z, Spearman P. Appendix I: collection and processing of human mucosal secretions. In:  Mestecky J, et al. editor. Mucosal Immunology. 3rd ed.. Amsterdam: Elsevier/Academic Press; 2005;p. 1829–1839
  9. Kaetzel CS, Mostov K. Immunoglobulin transport and the polymeric immunoglobulin receptor. In:  Mestecky J, et al. editor. Mucosal Immunology. 3rd ed.. Amsterdam: Elsevier/Academic Press; 2005;p. 211–250
  10. Kutteh WH, Mestecky J, Wira CR. Mucosal immunity in the human female reproductive tract. In:  Mestecky J, et al. editor. Mucosal Immunology. 3rd ed.. Amsterdam: Elsevier/Academic Press; 2005;p. 1631–1646
  11. Lamm ME. Protection of mucosal epithelia by IgA: intracellular neutralization and excretion of antigens. In:  Kaetzel CS editors. Mucosal Immune Defense: Immunoglobulin A, Springer Science+Business Media. New York: LLC; 2007;p. 173–182
  12. Liu MA. DNA vaccines: a review. J. Intern. Med. 2003;254:402–410
  13. Mascola JR, Stiegler G, VanCott TC, Katinger H, Carpenter CB, Hanson CE, et al. Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies. Nat. Med. 2000;6:207–210
  14. Mestecky J, Blumberg RS, Kiyono H, McGhee JR. The mucosal immune system. In:  Paul WE editors. Fundamental Immunology. 5th ed.. Philadelphia: Lippincott-Raven; 2003;p. 965–1020
  15. Mestecky J, Russell MW, Elson CO. Perspective on mucosal vaccines: is mucosal tolerance a barrier?. J. Immunol. 2007;179:5633–5638
  16. Mestecky J, Russell MW. Specific antibody activity, glycan heterogeneity and polyreactivity contribute to the protective activity of S-IgA at mucosal surfaces. Immunol. Lett. 2009;124:57–62
  17. Moingeon P, Batard T, Fadel R, Frati F, Sieber J, Van Overtvelt L. Immune mechanisms of allergen-specific sublingual immunotheraphy. Allergy. 2006;61:151–165
  18. Moldoveanu Z, Huang W-Q, Kulhavy R, Pate MS, Mestecky J. Human male genital tract secretions: both mucosal and systemic immune compartments contribute to the humoral immunity. J. Immunol. 2005;175:4127–4136
  19. Mowat AM, Fairia AMC, Weiner HL. Oral tolerance: physiologic basis and clinical applications. In:  Mestecky J, et al. editor. Mucosal Immunology. 3rd ed.. Amsterdam: Elsevier/Academic Press; 2005;p. 487–537
  20. Parr EL, Parr MB. Female genital tract infections and immunity in animal models. In:  Mestecky J, et al. editor. Mucosal Immunology. 3rd. ed.. Amsterdam: Elsevier/Academic Press; 2005;p. 1613–1630
  21. Quiding-Järbrink M, Nordström I, Granström G, Kilander A, Jertborn M, Butcher EC, et al. Differential expression of tissue-specific adhesion molecules on human circulating antibody-forming cells after systemic, enteric, and nasal immunizations. A molecular basis for the compartmentalization of effector B cell responses. J. Clin. Invest. 1997;99:1281–1286
  22. Raska M, Moldoveanu Z, Novak J, Hel Z, Novak L, Bozja J, et al. Delivery of DNA HIV-1 vaccine to the liver induces high and long-lasting humoral immune responses. Vaccine. 2008;26:1541–1551
  23. Renegar KB, Jackson GDF, Mestecky J. In vitro comparison of the biologic activities of monoclonal monomeric IgA, polymeric IgA, and secretory IgA. J. Immunol. 1998;160:1219–1223
  24. Russell MW, Kilian M. Biological activities of IgA. In:  Mestecky J, et al. editor. Mucosal Immunology. 3rd ed.. Amsterdam: Elsevier/Academic Press; 2005;p. 267–289
  25. Russell MW, Mestecky J. Humoral immune responses to microbial infections in the genital tract. Microbes Infect. 2002;4:667–677
  26. Russell, M.W., Mestecky, J., 2010. Tolerance versus protection against infection in the genital tract. Immunol. Invest. (in press).
  27. Russell MW, Sibley DA, Nikolova EB, Tomana M, Mestecky J. IgA antibody as a non-inflammatory regulator of immunity. Biochem. Soc. Trans. 1997;25:466–470
  28. Russell MW, Sparling PF, Morrison RP, Cauci S, Fidel PL, Martin D, et al. Mucosal immuology of sexually transmitted diseases. In:  Mestecky J, et al. editor. Mucosal Immunology. 3rd ed.. Amsterdam: Elsevier/Academic Press; 2005;p. 1693–1720
  29. Schiller JT, Lowy DR. Prospects for cervical cancer prevention by human papilloma virus vaccination. Cancer Res. 2006;66:10229–10232
  30. Song JH, Nguyen HH, Cuburu N, Horimoto T, Ko SY, Park SH, et al. Sublingual vaccination with influenza virus protects mice against lethal viral infection. Proc. Natl. Acad. Sci. U.S.A. 2008;105:1644–1649
  31. Underdown BJ. Parenteral immunization induces mucosal protection: A challenge to the mucosal immunity paradigm. In:  Mestecky J, et al. editor. Mucosal Immunology. 3rd. ed.. Amsterdam: Elsevier/Academic Press; 2005;p. 831–840
  32. Veazay RS, Shattock RJ, Pope M, Kirijan JC, Jones J, Hu Q, et al Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120. Nat. Med. 2003;9:343–346
  33. Woof JM, Mestecky J. Mucosal immunoglobulins. Immunol. Rev. 2005;206:64–82
  34. Wu H-Y, Russell MW. Nasal lymphoid tissue, intranasal immunization, and compartmentalization of the common mucosal immune system. Immunol. Res. 1997;16:187–201
  35. Zinkernagel RM, Hengartner H. Antiviral immunity. Immunol. Today. 1997;18:258–260

PII: S0165-0378(10)00045-8

doi: 10.1016/j.jri.2010.02.003

Journal of Reproductive Immunology
Volume 85, Issue 1 , Pages 81-85 , May 2010