Journal of Reproductive Immunology
Volume 85, Issue 1 , Pages 112-116 , May 2010

Beyond the threshold: an etiological bridge between hypoxia and immunity in preeclampsia

Received 10 September 2009 ,Revised 15 January 2010 ,Accepted 22 January 2010.

References 

  1. ACOG Committee on Practice Bulletins—Obstetrics . ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Obstet. Gynecol. 2002;99:159–167
  2. Ashkar AA, Di Santo JP, Croy BA. Interferon γ contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy. J. Exp. Med. 2000;192:259–269
  3. Brosens I, Dixon HG, Robertson WB. Fetal growth retardation and the arteries of the placental bed. Br. J. Obstet. Gynaecol. 1977;84:656–663
  4. Burton GJ, Woods AW, Jauniaux E, Kingdom JC. Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy. Placenta. 2009;30:473–482
  5. Crocker IP, Cooper S, Ong SC, Baker PN. Altered cell kinetics in cultured placental villous explants in pregnancies complicated by preeclampsia and intra-uterine growth restriction. J. Pathol. 2004;204:11–18
  6. Dekker G, Sibai B. Primary, secondary and tertiary prevention of pre-eclampsia. Lancet. 2001;357:209–215
  7. De Wolf F, Brosens I, Robertson WB. Ultrastructure of uteroplacental arteries. Contrib. Gynecol. Obstet. 1982;9:86–99
  8. Gilbert JS, Ryan MJ, LaMarca BB, Sedeek M, Murphy SR, Granger JP. Pathophysiology of hypertension during preeclampsia: linking placental ischemia with endothelial dysfunction. Am. J. Physiol. Heart Circ. Physiol. 2008;294:541–550
  9. Hanna J, Goldman-Wohl D, Hamani Y, Avraham I, Greenfield C, Natanson-Yaron S, et al. Decidual NK cells regulate key developmental processes at the human fetal–maternal interface. Nat. Med. 2006;12:1065–1074
  10. Hanna N, Hanna I, Hleb M, Wagner E, Dougherty J, Balkundi D, et al. Gestational age-dependent expression of IL-10 and its receptor in human placental tissues and isolated cytotrophoblasts. J. Immunol. 2000;164:5721–5728
  11. Hung TH, Skepper JN, Charnock-Jones SD, Burton GJ. Hypoxia reoxygenation. A potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia. Circ. Res. 2002;90:1274–1281
  12. Hung TH, Burton GJ. Hypoxia and reoxygenation: a possible mechanism for placental oxidative stress in preeclampsia. Taiwan J. Obstet. Gynecol. 2006;45:189–200
  13. Ilekis J, Reddy UM, Roberts JM. Preeclampsia—a pressing problem: an executive summary of a National Institute of Child Health and Human Development workshop. Reprod. Sci. 2007;14:508–523
  14. Irgens HU, Reisaeter L, Irgens LM, Lie RT. Long term mortality of mothers and fathers after preeclampsia: population based cohort study. Br. Med. J. 2001;323:1213–1217
  15. Kalkunte S, Lai Z, Tewari N, Chichester C, Romero R, Padbury J, et al. In vitro and in vivo evidence for lack of endovascular remodeling by third trimester trophoblasts. Placenta. 2008;29:871–878
  16. Kalkunte S, Mselle TF, Norris WE, Wira CR, Sentman CL, Sharma S. VEGF C facilitates immune tolerance and endovascular activity of human uterine NK cells at the maternal–fetal interface. J. Immunol. 2009;182:4085–4092
  17. Karumanchi SA, Stillman IE. In vivo rat model of preeclampsia. Methods Mol. Med. 2006;122:393–399
  18. Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, et al. Circulating angiogenic factors and the risk of preeclampsia. N. Engl. J. Med. 2004;350:672–683
  19. Levy R, Smith SD, Yusuf K, Huettner PC, Kraus FT, Sadovsky Y, et al. Trophoblasts apoptosis from pregnancies complicated by fetal growth restriction is associated with enhanced p53 expression. Am. J. Obstet. Gynecol. 2002;186:1056–1061
  20. Li JQ, Qi HZ, He ZJ, Hu W, Si ZZ, Li YN, et al. Cytoprotective effects of human interleukin-10 gene transfer against necrosis and apoptosis induced by hepatic cold ischemia/reperfusion injury. J. Surg. Res. 2009;157:e71–e78
  21. Maltepe E, Krampitz GW, Okazaki KM, Red-Horse K, Mak W, Simon MC, et al. Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta. Development. 2005;32:3393–3403
  22. Meekins JW, Pijnenborg R, Hanssens M, McFadyen IR, van Asshe A. A study of placental bed spiral arteries and trophoblast invasion in normal and severe pre-eclamptic pregnancies. Br. J. Obstet. Gynaecol. 1994;101:669–674
  23. Moore-Maxwell CA, Robboy SJ. Placental site trophoblastic tumor arising from antecedent molar pregnancy. Gynecol. Oncol. 2004;92:708–712
  24. Murphy SP, Fast LD, Hanna NN, Sharma S. Uterine NK cells mediate inflammation-induced fetal demise in IL-10-null mice. J. Immunol. 2005;175:4084–4090
  25. Murphy SP, Hanna NN, Fast LD, Shaw S, Berg G, Padbury JF, et al. Evidence for participation of uterine natural killer cells in the mechanisms responsible for spontaneous preterm labor and delivery. Am. J. Obstet. Gynecol. 2009;200(308):e1–e9
  26. Nevo O, Soleymanlou N, Wu Y, Xu J, Kingdom J, Many A, et al. Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006;355:992–1005
  27. Nizet V, Johnson RS. Interdependence of hypoxic and innate immune responses. Nat. Rev. Immunol. 2009;9:609–617
  28. Pijnenborg R, Vercruysse L, Hanssens M. The uterine spiral arteries in human pregnancy: facts and controversies. Placenta. 2006;27:939–958
  29. Plevyak M, Hanna N, Mayer S, Murphy S, Pinar H, Fast L, et al. Deficiency of decidual IL-10 in first trimester missed abortion: a lack of correlation with the decidual immune cell profile. Am. J. Reprod. Immunol. 2002;47:242–250
  30. Redman CWG, Sargent IL. Placental debris, oxidative stress and preeclampsia. Placenta. 2000;21:597–602
  31. Roberts JM, Hubel CA. Is oxidative stress the link in the two-stage model of preeclampsia. Lancet. 1999;354:788–789
  32. Romero R, Nien JK, Espinoza J, Todem D, Fu W, Chung H, et al. A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate. J. Matern. Fetal Neonatal Med. 2008;21:9–23
  33. Rosario GX, Konno T, Soares MJ. Maternal hypoxia activates endovascular trophoblast cell invasion. Dev. Biol. 2008;314:362–375
  34. Sibai B, Dekker G, Kupferminic M. Preeclampsia. Lancet. 2005;353:785–799
  35. Thadhani R, Mutter WP, Wolf M, Levine RJ, Taylor RN, Sukhatme VP, et al. First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia. J. Clin. Endocrinol. Metab. 2004;89:770–775
  36. Thaxton JE, Romero R, Sharma S. TLR9 activation coupled to IL-10 deficiency induces adverse pregnancy outcomes. J. Immunol. 2009;183:1144–1154
  37. Xiong Y, Liebermann DA, Tront JS, Holtzman EJ, Huang Y, Hoffman B, et al. Gadd45a stress signaling regulates sFlt-1 expression in preeclampsia. J. Cell Physiol. 2009;220:632–639
  38. Xiong Y, Liebermann DA, Holtzman EJ, Hoffman B, Geifman-Holtzman O. Hypoxia regulates sFlt-1 secretion via Gadd45a-p38 stress response pathway. Am. J. Obstet. Gynecol. 2009;199:S204
  39. Zhou Y, Fisher SJ, Janatpor M, Genbacev O, Dejana E, Wheelock M, et al. Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion. J. Clin. Invest. 1997;99:2139–2151
  40. Zhou Y, Damsky CH, Chiu K, Roberts JM, Fisher SJ. Preeclampsia is associated with abnormal expression of adhesion molecules by invasive cytotrophoblasts. J. Clin. Invest. 1993;91:950–960

PII: S0165-0378(10)00036-7

doi: 10.1016/j.jri.2010.01.002

Journal of Reproductive Immunology
Volume 85, Issue 1 , Pages 112-116 , May 2010

Article Tools

* Image Usage & Resolution