Journal of Reproductive Immunology
Volume 84, Issue 2 , Pages 164-170 , March 2010

Increased prevalence of T helper 17 (Th17) cells in peripheral blood and decidua in unexplained recurrent spontaneous abortion patients

  • Wen-Juan Wang

      Affiliations

    • Department of Obstetrics and Gynecology; Renji Hospital, Shanghai Jiao Tong University School of Medicine, 145 Shandong Mid Road, Shanghai 200001, China
    • Reproduction Medical Center, Yantai Yuhuangding Hospital of Qingdao University Medical College, Yantai 264000, China
    • ,
  • Cui-Fang Hao

      Affiliations

    • Reproduction Medical Center, Yantai Yuhuangding Hospital of Qingdao University Medical College, Yantai 264000, China
    • ,
  • Yi-Lin

      Affiliations

    • Department of Obstetrics and Gynecology; Renji Hospital, Shanghai Jiao Tong University School of Medicine, 145 Shandong Mid Road, Shanghai 200001, China
    • ,
  • Guang-Jie Yin

      Affiliations

    • Department of Obstetrics and Gynecology; Renji Hospital, Shanghai Jiao Tong University School of Medicine, 145 Shandong Mid Road, Shanghai 200001, China
    • ,
  • Shi-Hua Bao

      Affiliations

    • Department of Obstetrics and Gynecology; Renji Hospital, Shanghai Jiao Tong University School of Medicine, 145 Shandong Mid Road, Shanghai 200001, China
    • ,
  • Li-Hua Qiu

      Affiliations

    • Department of Obstetrics and Gynecology; Renji Hospital, Shanghai Jiao Tong University School of Medicine, 145 Shandong Mid Road, Shanghai 200001, China
    • ,
  • Qi-De Lin

      Affiliations

    • Department of Obstetrics and Gynecology; Renji Hospital, Shanghai Jiao Tong University School of Medicine, 145 Shandong Mid Road, Shanghai 200001, China
    • Corresponding Author InformationCorresponding author. Tel.: +86 21 53882016; fax: +86 21 63730455.

Received 19 June 2009 ,Revised 7 December 2009 ,Accepted 14 December 2009.

References 

  1. Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006;441:235–238
  2. Cheng X, Yu X, Ding YJ, Fu QQ, Xie JJ, Tang TT, et al. The Th17/Treg imbalance in patients with acute coronary syndrome. Clin. Immunol. 2008;127:89–97
  3. Favre D, Lederer S, Kanwar B, Ma ZM, Proll S, Kasakow Z, et al. Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection. PLoS Pathog. 2009;5:e1000295
  4. Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 2005;6:1123–1132
  5. Hill JA. T helper 1 immunity to trophoblast: evidence for a new immunological mechanism for recurrent abortion in women. Hum. Reprod. 1995;10:114–120
  6. Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+T helper cells. Cell. 2006;126:1121–1133
  7. Iwakura Y, Ishigame H. The IL-23/IL-17 axis in inflammation. J. Clin. Invest. 2006;116:1218–1222
  8. Klentzeris LD, Bulmer JN, Warren MA, Morrison L, Li TC, Cooke ID. Lymphoid tissue in the endometrium of women with unexplained infertility: morphometric and immunohistochemical aspects. Hum. Reprod. 1994;9:646–652
  9. Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J. Exp. Med. 2006;203:1701–1711
  10. Li J, Simeoni E, Fleury S, Fiorini E, Kappenberger L, von Segesser LK, et al. Gene transfer of soluble interleukin-17 receptor prolongs cardiac allograft survival in a rat model. Eur. J. Cardiothorac. Surg. 2006;29:779–783
  11. Lohr J, Knoechel B, Wang JJ, Villarino AV, Abbas AK. Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease. J. Exp. Med. 2006;203:2785–2791
  12. Loong CC, Hsieh HG, Lui WY, Chen A, Lin CY. Evidence for the early involvement of interleukin 17 in human and experimental renal allograft rejection. J. Pathol. 2002;197:322–332
  13. Manel N, Unutmaz D, Littman DR. The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat. Immunol. 2008;9:641–649
  14. McGeachy MJ, Cua DJ. Th17 cell differentiation: the long and winding road. Immunity. 2008;28:445–453
  15. Medawar PB. Some immunological and endocrinological problems raised by the evolution of viviparity in vertebrates. Symp. Soc. Exp. Biol. 1953;7:320–338
  16. Ogura H, Murakami M, Okuyama Y, Tsuruoka M, Kitabayashi C, Kanamoto M, et al. Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction. Immunity. 2008;29:628–636
  17. Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 2005;6:1133–1141
  18. Piccinni MP, Beloni L, Livi C, Maggi E, Scarselli G, Romagnani S. Defective production of both leukaemia inhibitory factor and type 2 T helper cytokines by decidual T cells in unexplained recurrent abortions. Nat. Med. 1998;4:1020–1024
  19. Sasaki Y, Sakai M, Miyazaki S, Higuma S, Shiozaki A, Saito S. Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases. Mol. Hum. Reprod. 2004;10:347–353
  20. Saito S, Sasaki Y, Sakai M. CD4(+)CD25high regulatory T cells in human pregnancy. J. Reprod. Immunol. 2005;65:111–120
  21. Seddiki N, Santner-Nanan B, Martinson J, Zaunders J, Sasson S, Landay A, et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J. Exp. Med. 2006;203:1693–1700
  22. Tang JL, Subbotin VM, Antonysamy MA, Troutt AB, Rao AS, Thomson AW. Interleukin-17 antagonism inhibits acute but not chronic vascular rejection. Transplantation. 2001;72:348–350
  23. Trowsdale J, Betz AG. Mother's little helpers: mechanisms of maternal–fetal tolerance. Nat. Immunol. 2006;7:241–246
  24. Van Kooten C, Boonstra JG, Paape ME, Fossiez F, Banchereau J, Lebecque S, et al. Interleukin-17 activates human renal epithelial cells in vitro and is expressed during renal allograft rejection. J. Am. Soc. Nephrol. 1998;9:1526–1534
  25. World Health Organization . Laboratory Manual for the Examination of Human Semen and Sperm–Cervical Mucus Interaction. New York: Cambridge University Press; 1999;
  26. Yang H, Qiu L, Di W, Zhao A, Chen G, Hu K, et al. Proportional change of CD4+CD25+ regulatory T cells in decidua and peripheral blood in unexplained recurrent spontaneous abortion patients. Fertil. Steril. 2008;89:656–661

☆ This work was supported by the National Natural Science Foundation of China (Shanghai) (30530740).

PII: S0165-0378(10)00009-4

doi: 10.1016/j.jri.2009.12.003

Journal of Reproductive Immunology
Volume 84, Issue 2 , Pages 164-170 , March 2010

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