Journal of Reproductive Immunology
Volume 84, Issue 2 , Pages 171-175 , March 2010

Genetic polymorphism in an inflammasome component, cervical mycoplasma detection and female infertility in women undergoing in vitro fertilization

  • Steven S. Witkin

      Affiliations

    • Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY, USA
    • Corresponding Author InformationCorresponding author at: Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, 525 East 6th Street, Box 35, New York, NY 10065, USA. Tel.: +1 212 746 3165; fax: +1 212 746 8799.
    • ,
  • Katrin Bierhals

      Affiliations

    • Infertility Center Dortmund, Dortmund, Germany
    • ,
  • Iara Linhares

      Affiliations

    • Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY, USA
    • Department of Gynecology, University of Sao Paulo Medical School and Hospital das Clinicas, Sao Paulo, Brazil
    • ,
  • Neil Normand

      Affiliations

    • Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY, USA
    • ,
  • Stefan Dieterle

      Affiliations

    • Infertility Center Dortmund, Dortmund, Germany
    • Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Witten/Herdecke, Dortmund, Germany
    • ,
  • Andreas Neuer

      Affiliations

    • Infertility Center Dortmund, Dortmund, Germany

Received 21 September 2009 ,Revised 29 October 2009 ,Accepted 23 November 2009.

References 

  1. Aganna E, Martinon F, Hawkins PN, Ross JB, Swan DC, Booth DR, et al. Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis. Arthritis Rheum. 2002;46:2445–2452
  2. Babayan A, Neuer A, Dieterle S, Bongiovanni AM, Witkin SS. Hyaluronan in follicular fluid and embryo implantation following in vitro fertilization and embryo transfer. J. Assist. Reprod. Genet. 2008;25:473–476
  3. Baczynska A, Friis Sven Strup H, Fedder J, Birkelund S, Christiansen G. The use of enzyme-linked immunosorbent assay for detection of Mycoplasma hominis antibodies in infertile women serum samples. Hum. Reprod. 2005;20:1277–1285
  4. Cole BC. Mycoplasma interactions with the immune system: implications for disease pathology. ASM News. 1996;62:471–475
  5. Dahm-Kahler P, Ghahremani M, Lind AK, Sundfeldt K, Brannstrom M. Monocyte chemotactic protein-1 (MCP-1), its receptor, and macrophages in the perifollicular stroma during the human ovulatory process. Fertil. Steril. 2009;91:231–239
  6. Dinarello CA. Interleukin-1β, interleukin 18, and the interleukin-1β converting enzyme. Ann. NY Acad. Sci. 1998;856:1–11
  7. Doh K, Barton PT, Korneeva I, Perni SC, Bongiovanni AM, Tuttle SL, et al. Differential vaginal expression of interleukin-I system cytokines in the presence of Mycoplasma hominis and Ureaplasma urealyticum in pregnant women. Infect. Dis. Obstet. Gynecol. 2004;12:79–85
  8. Fernandes-Alnemri T, Wu J, Yu JW, Datta P, Miller B, Jankowski W, et al. The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ. 2007;14:1590–1604
  9. Fernandes-Alnemri T, Yu JW, Datta P, Wu J, Alnemri ES. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature. 2009;458:509–513
  10. Genc MR, Gerber S, Nesin M, Witkin SS. Polymorphism in the interleukin-1 gene complex and spontaneous preterm delivery. Am. J. Obstet. Gynecol. 2002;157–163
  11. Hoffman HM, Mueller JL, Broide DH, Wanderer AA, Kolodner RD. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome. Nat. Genet. 2001;29:301–305
  12. Hvid M, Baczynska A, Deleuran B, Fedder J, Knudsen HJ, Christiansen G, et al. Interleukin-1 is the initiator of Fallopian tube destruction during Chlamydia trachomatis infection. Cell Microbiol. 2007;9:2795–2803
  13. Kamiyama S, Teruya Y, Nohara M, Kanazawa K. Impact of detection of bacterial endotoxin in menstrual effluent on the pregnancy rate in in vitro fertilization and embryo transfer. Fertil. Steril. 2004;82:788–792
  14. Kanneganti TD, Ozoren N, Body-Malapel M, Amer A, Park JH, Franchi L, et al. Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature. 2006;440:233–236
  15. Kummer JA, Broekhuizen R, Everett H, Agostini L, Kuijk L, Martinon F, et al. Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response. J. Histochem. Cytochem. 2007;55:443–452
  16. Lev-Sagie A, Prus D, Linhares IM, Lavy Y, Ledger WJ, Witkin SS. Polymorphism in a gene coding for the inflammasome component NALP3 and recurrent vulvovaginal candidiasis in women with vulvar vestibulitis syndrome. Am. J. Obstet. Gynecol. 2009;200:303.e1–303.e6
  17. Lim KJH, Odukoya OA, Ajjan RA, Li TC, Weetman AP, Cooke ID. Profile of cytokine mRNA expression in peri-implantation human endometrium. Mol. Hum. Reprod. 1998;4:77–81
  18. Mariathasan S, Weiss DS, Newton K, McBride J, O’Rourke K, Roose-Girma M, et al. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature. 2006;440:228–232
  19. Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 2006;440:237–241
  20. Omi T, Kumada M, Kamesaki T, Okuda H, Munkhtulga Y, Utsumi N, et al. An intronic variable number of tandem repeat polymorphisms of the cold-induced autoinflammatory syndrome 1 (CIAS1) gene modifies gene expression and is associated with essential hypertension. Eur. J. Hum. Genet. 2006;14:1295–1305
  21. Romero R, Espinoza J, Mazor M. Can endometrial infection/inflammation explain implantation failure, spontaneous abortion, and preterm birth after in vitro fertilization?. Fertil. Steril. 2004;82:799–804
  22. Ryckmann KK, Williams SM, Kalinka J. Correlations of selected vaginal cytokine levels with pregnancy-related traits in women with bacterial vaginosis and mycoplasmas. J. Reprod. Immunol. 2008;78:172–180
  23. Salim R, Ben-Shlomo I, Colodner R, Keness Y, Shalev E. Bacterial colonization of the uterine cervix and success rate in assisted reproduction: results of a prospective survey. Hum. Reprod. 2002;17:337–340
  24. Taylor-Robinson D. Infections due to species of Mycoplasma and Ureaplasma: an update. Clin. Infect. Dis. 1996;23:671–684
  25. Thole JER, Hindersson P, de Bruyn J, Cremers F, van der Zee J, de Cock H, et al. Antigenic relatedness of a strongly immunogenic 65 kDa mycobacterial protein antigen with a similarly sized ubiquitous bacterial common antigen. Microb. Pathogenesis. 1988;4:71–83
  26. Tschopp J, Martinon F, Burns K. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol. 2003;4:95–104
  27. Uuskula A, Kohl PK. Genital mycoplasma, including Mycoplasma genitalium, as sexually transmitted agents. Int. J. STD AIDS. 2002;13:79–85
  28. Wegmann TG, Lin H, Guilbert L, Mosmann TR. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a [TH2] phenomenon?. Immunol. Today. 1993;14:353–356
  29. Yu JW, Wu J, Zhang Z, Datta P, Ibrahim I, Taniguchi S, et al. Cryopyrin and oyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization. Cell Death Differ. 2006;13:236–249

PII: S0165-0378(09)00555-5

doi: 10.1016/j.jri.2009.11.005

Journal of Reproductive Immunology
Volume 84, Issue 2 , Pages 171-175 , March 2010

Article Tools