Journal of Reproductive Immunology
Volume 84, Issue 1 , Pages 95-99 , January 2010

Anti-β2 glycoprotein-I antibody increases the risk of pregnancy-induced hypertension: a case-controlled study

  • Hideto Yamada

      Affiliations

    • Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho Chuo-ku, Kobe 650-0017, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 78 382 6000; fax: +81 78 382 5756.
    • ,
  • Tatsuya Atsumi

      Affiliations

    • Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    • ,
  • Olga Amengual

      Affiliations

    • Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    • ,
  • Takao Koike

      Affiliations

    • Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    • ,
  • Itsuko Furuta

      Affiliations

    • Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    • ,
  • Kaori Ohta

      Affiliations

    • Molecular Biostatistics Research Team, Research Center for Charged Particle Therapy, National Institute of Radiological Science, Chiba, Japan
    • ,
  • Gen Kobashi

      Affiliations

    • Molecular Biostatistics Research Team, Research Center for Charged Particle Therapy, National Institute of Radiological Science, Chiba, Japan

Received 1 May 2009 ,Revised 25 September 2009 ,Accepted 1 October 2009.

References 

  1. Ailus K, Tulppala M, Palosuo T, Ylikorkala O, Vaarala O. Antibodies to beta 2-glycoprotein I and prothrombin in habitual abortion. Fertil. Steril. 1996;66:937–941
  2. Amengual O, Atsumi T, Khamashta M, Koike T, Hughes GRV. Specificity of ELISA for antibody to beta2-glycoprotein I in patients with anti-phospholipid syndrome. Br. J. Rheumatol. 1996;35:1239–1243
  3. Arnold J, Holmes Z, Pickering W, Farmer C, Regan L, Cohen H. Anti-beta 2 glycoprotein 1 and anti-annexin V antibodies in women with recurrent miscarriage. Br. J. Haematol. 2001;113:911–914
  4. de Laat B, Derksen RH, Urbanus RT, de Groot PG. IgG antibodies that recognize epitope Gly40-Arg43 in domain I of beta 2-glycoprotein I cause lupus anticoagulantC, and their presence correlates strongly with thrombosis. Blood. 2004;105:1540–1545
  5. D’Ippolito S, Di Simone N, Di Nicuolo F, Castellani R, Caruso A. Antiphospholipid antibodies: effects on trophoblast and endothelial cells. Am. J. Reprod. Immunol. 2007;58:150–158
  6. Di Simone N, Raschi E, Testoni C, Castellani R, D’Asta M, Shi T, et al. Pathogenic role of anti-beta 2-glycoprotein I antibodies in antiphospholipid associated fetal loss: characterisation of beta 2-glycoprotein I binding to trophoblast cells and functional effects of anti-beta 2-glycoprotein I antibodies in vitro. Ann. Rheum. Dis. 2005;64:462–467
  7. Di Simone N, Meroni PL, D’Asta M, Di Nicuolo F, D’Alessio MC, Caruso A. Pathogenic role of anti-beta2-glycoprotein I antibodies on human placenta: functional effects related to implantation and roles of heparin. Hum. Reprod. Update. 2007;13:189–196
  8. Falcón CR, Martinuzzo ME, Forastiero RR, Cerrato GS, Carreras LO. Pregnancy loss and autoantibodies against phospholipid-binding proteins. Obstet. Gynecol. 1997;89:975–980
  9. Faden D, Tincani A, Tanzi P, Spatola L, Lojacono A, Tarantini M, et al. Anti-beta 2 glycoprotein I antibodies in a general obstetric population: preliminary results on the prevalence and correlation with pregnancy outcome. Anti-beta2 glycoprotein I antibodies are associated with some obstetrical complications, mainly preeclampsia–eclampsia. Eur. J. Obstet. Gynecol. Reprod. Biol. 1997;73:37–42
  10. Forastiero RR, Martinuzzo ME, Cerrato GS, Kordich LC, Carreras LO. Relationship of anti beta2-glycoprotein I and anti prothrombin antibodies to thrombosis and pregnancy loss in patients with antiphospholipid antibodies. Thromb. Haemost. 1997;78:1008–1014
  11. Hulstein JJ, Lenting PJ, de Laat B, Derksen RH, Fijnheer R, de Groot PG. beta2-Glycoprotein I inhibits von Willebrand factor dependent platelet adhesion and aggregation. Blood. 2007;110:1483–1491
  12. Lee RM, Emlen W, Scott JR, Branch DW, Silver RM. Anti-beta2-glycoprotein I antibodies in women with recurrent spontaneous abortion, unexplained fetal death, and antiphospholipid syndrome. Am. J. Obstet. Gynecol. 1999;181:642–648
  13. Lee RM, Brown MA, Branch DW, Ward K, Silver RM. Anticardiolipin and anti-beta2-glycoprotein-I antibodies in preeclampsia. Obstet. Gynecol. 2003;102:294–300
  14. Lynch A, Byers T, Emlen W, Rynes D, Shetterly SM, Hamman RF. Association of antibodies to beta2-glycoprotein 1 with pregnancy loss and pregnancy-induced hypertension: a prospective study in low-risk pregnancy. Obstet. Gynecol. 1999;93:193–198
  15. Martinuzzo ME, Forastiero RR, Carreras LO. Anti beta 2 glycoprotein I antibodies: detection and association with thrombosis. Br. J. Haematol. 1995;89:397–402
  16. Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J. Thromb. Haemost. 2006;4:295–306
  17. Pengo V, Biasiolo A, Pegoraro C, Cucchini U, Noventa F, Iliceto S. Antibody profiles for the diagnosis of antiphospholipid syndrome. Thromb. Haemost. 2005;93:1147–1152
  18. Sailer T, Zoghlami C, Kurz C, Rumpold H, Quehenberger P, Panzer S, et al. Anti-beta2-glycoprotein I antibodies are associated with pregnancy loss in women with the lupus anticoagulant. Thromb. Haemost. 2006;95:796–801
  19. Sanmarco M, Gayet S, Alessi MC, Audrain M, de Maistre E, Gris JC, et al. Antiphosphatidylethanolamine antibodies are associated with an increased odds ratio for thrombosis. Thromb. Haemost. 2007;97:949–954
  20. Stern C, Chamley L, Hale L, Kloss M, Speirs A, Baker HW. Antibodies to beta2 glycoprotein I are associated with in vitro fertilization implantation failure as well as recurrent miscarriage: results of a prevalence study. Fertil. Steril. 1998;70:938–944
  21. Wilson WA, Gharavi AE, Koike T, Lockshin MD, Branch DW, Piette JC, et al. International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop. Arthritis Rheum. 1999;42:1309–1311
  22. Yamada H, Atsumi T, Kobashi G, Ota C, Kato EH, Tsuruga N, et al. Antiphospholipid antibodies increase the risk of pregnancy-induced hypertension and adverse pregnancy outcomes. J. Reprod. Immunol. 2009;79:188–195
  23. Zanon E, Prandoni P, Vianello F, Saggiorato G, Carraro G, Bagatella P, et al. Anti-beta2-glycoprotein I antibodies in patients with acute venous thromboembolism: prevalence and association with recurrent thromboembolism. Thromb. Res. 1999;96:269–274
  24. Zoghlami-Rintelen C, Vormittag R, Sailer T, Lehr S, Quehenberger P, Rumpold H, et al. The presence of IgG antibodies against beta2-glycoprotein I predicts the risk of thrombosis in patients with the lupus anticoagulant. J. Thromb. Haemost. 2005;3:1160–1165

PII: S0165-0378(09)00522-1

doi: 10.1016/j.jri.2009.10.005

Journal of Reproductive Immunology
Volume 84, Issue 1 , Pages 95-99 , January 2010

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