Journal of Reproductive Immunology
Volume 83, Issue 1 , Pages 124-127 , December 2009

The role of glycodelin as an immune-modulating agent at the feto–maternal interface

  • Anshula Alok

      Affiliations

    • Recipient of Senior Research Fellowship from the University Grants Commission, Government of India.
    • ,
  • Anjali A. Karande

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +91 80 2293 2306; fax: +91 80 2360 0814.

Received 11 December 2008 ,Revised 15 May 2009 ,Accepted 26 June 2009.

References 

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  2. Alok A, Mukhopadhyay D, Karande AA. Glycodelin A, an immunomodulatory protein in the endometrium, inhibits proliferation and induces apoptosis in monocytic cells. Int. J. Biochem. Cell Biol. 2009;41:1138–1147
  3. Bolton AE, Pockley AG, Clough KJ, Mowles EA, Stoker RJ, Westwood OM. Identification of placental protein 14 as an immunosuppressive factor in human reproduction. Lancet. 1987;1:593–595
  4. Kwak-Kim J, Gilman-Sachs A. Clinical implication of natural killer cells and reproduction. Am. J. Reprod. Immunol. 2008;59:388–400
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  8. Mukhopadhyay D, Sundereshan S, Rao C, Karande AA. Placental protein 14 induces apoptosis in T cells but not in monocytes. J. Biol. Chem. 2001;276:28268–28273
  9. Okamoto N, Uchida A, Takakura K, Kariya Y, Kanzaki H, Riittinen L. Suppression by human placental protein 14 of natural killer cell activity. Am. J. Reprod. Immunol. 1991;26:137–142
  10. Pockley AG, Bolton AE. Placental protein 14 (PP14) inhibits the synthesis of interleukin-2 and the release of soluble interleukin-2 receptors from phytohaemagglutinin-stimulated lymphocytes. Clin. Exp. Immunol. 1989;77:252–256
  11. Scholz C, Toth B, Brunnhuber R, Rampf E, Weissenbacher T, Santoso L, et al. Glycodelin A induces a tolerogenic phenotype in monocyte-derived dendritic cells in vitro. Am. J. Reprod. Immunol. 2008;60:501–512
  12. Seppala M, Taylor RN, Koistinen H, Koistinen R, Milgrom E. Glycodelin: a major lipocalin protein of the reproductive axis with diverse actions in cell recognition and differentiation. Endocr. Rev. 2002;23:401–430
  13. SundarRaj S, Mukhopadhyay D, Karande AA. Glycodelin A triggers mitochondrial stress and apoptosis in T cells by a mechanism distinct and independent of TCR signaling. Mol. Immunol. 2008;45:2391–2400
  14. Vigne JL, Hornung D, Mueller MD, Taylor RN. Purification and characterisation of an immunomodulatory endometrial protein. Glycodelin. J. Biol. Chem. 2001;276:17101–17105
  15. Yaniv E, Borovsky Z, Mishan-Eisenberg G, Rachmilewitz J. Placental protein 14 regulates selective B cell responses. Cell. Immunol. 2003;222:1156–1163

PII: S0165-0378(09)00466-5

doi: 10.1016/j.jri.2009.06.261

Journal of Reproductive Immunology
Volume 83, Issue 1 , Pages 124-127 , December 2009

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