Journal of Reproductive Immunology
Volume 83, Issue 1 , Pages 106-108 , December 2009

The regulatory role of thymic stromal lymphopoietin (TSLP) in maternal–fetal immune tolerance during early human pregnancy

  • Da-Jin Li

      Affiliations

    • Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, IBS, Fudan University Shanghai Medical College, Shanghai, 200011, China
    • Department of Obstetrics & Gynecology, Hainan Medical College Affiliated Hospital, Haikou 570102, China
    • Corresponding Author InformationCorresponding author at: Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, IBS, Fudan University Shanghai Medical College, Shanghai, 200011, China.
    • ,
  • Pei-Fen Guo

      Affiliations

    • Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, IBS, Fudan University Shanghai Medical College, Shanghai, 200011, China

Received 11 March 2009 ,Revised 14 July 2009 ,Accepted 21 July 2009.

References 

  1. Ito T, Wang YH, Duramad O, Hori T, Delespesse GJ, Watanabe N, et al. TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J. Exp. Med. 2005;202:1213–1223
  2. Reche PA, Soumelis V, Gorman DM, Clifford T, Liu M, Travis M, et al. Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. J. Immunol. 2001;167:336–343
  3. Rimoldi M, Chieppa M, Salucci V, Avogadri F, Sonzogni A, Sampietro GM, et al. Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nat. Immunol. 2005;6:507–514
  4. Soumelis V, Reche PA, Kanzler H, Yuan W, Edward G, Homey B, et al. Human epithelial cells trigger dendritic cell-mediated allergic inflammation by producing TSLP. Nat. Immunol. 2002;3:673–680
  5. Tilburgs T, Roelen DL, van der Mast BJ, de Groot-Swings GM, Kleijburg C, Scherjon SA, et al. Evidence for a selective migration of fetus-specific CD4+CD25 bright regulatory T cells from the peripheral blood to the decidua in human pregnancy. J. Immunol. 2008;180:5737–5745
  6. Wang YH, Angkasekwinai P, Lu N, Voo KS, Arima K, Hanabuchi S, et al. IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. J. Exp. Med. 2007;204:1837–1847
  7. Uemura Y, Suzuki M, Liu TY, Narita Y, Hirata S, Ohyama H, et al. Role of human non-invariant NKT lymphocytes in the maintenance of type 2 T helper environment during pregnancy. Int. Immunol. 2008;20:405–412
  8. Ying S, O’Connor B, Ratoff J, Meng Q, Mallett K, Cousins D, et al. Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. J. Immunol. 2005;174:8183–8190
  9. Yoo J, Omori M, Gyarmati D, Zhou B, Aye T, Brewer A, et al. Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin. J. Exp. Med. 2005;202:541–549

PII: S0165-0378(09)00462-8

doi: 10.1016/j.jri.2009.07.015

Journal of Reproductive Immunology
Volume 83, Issue 1 , Pages 106-108 , December 2009

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