Journal of Reproductive Immunology
Volume 83, Issue 1 , Pages 134-138 , December 2009

Novel approaches for mechanistic understanding and predicting preeclampsia

  • Satyan Kalkunte

      Affiliations

    • Department of Pediatrics, Women and Infants Hospital-Warren Alpert Medical School of Brown University, 101 Dudley Street, Providence, RI, USA
    • ,
  • Zhongbin Lai

      Affiliations

    • Department of Pediatrics, Women and Infants Hospital-Warren Alpert Medical School of Brown University, 101 Dudley Street, Providence, RI, USA
    • ,
  • Wendy E. Norris

      Affiliations

    • Department of Pediatrics, Women and Infants Hospital-Warren Alpert Medical School of Brown University, 101 Dudley Street, Providence, RI, USA
    • ,
  • Linda A. Pietras

      Affiliations

    • Department of Pediatrics, Women and Infants Hospital-Warren Alpert Medical School of Brown University, 101 Dudley Street, Providence, RI, USA
    • ,
  • Neetu Tewari

      Affiliations

    • Department of Pediatrics, Women and Infants Hospital-Warren Alpert Medical School of Brown University, 101 Dudley Street, Providence, RI, USA
    • ,
  • Roland Boij

      Affiliations

    • Department of Pediatrics, Women and Infants Hospital-Warren Alpert Medical School of Brown University, 101 Dudley Street, Providence, RI, USA
    • ,
  • Stefan Neubeck

      Affiliations

    • Placenta-Lab, Department of Obstetrics, Friedrich-Schiller-Universität, Jena, Germany
    • ,
  • Udo R. Markert

      Affiliations

    • Placenta-Lab, Department of Obstetrics, Friedrich-Schiller-Universität, Jena, Germany
    • ,
  • Surendra Sharma

      Affiliations

    • Department of Pediatrics, Women and Infants Hospital-Warren Alpert Medical School of Brown University, 101 Dudley Street, Providence, RI, USA
    • Corresponding Author InformationCorresponding author.

Received 13 March 2009 ,Revised 19 August 2009 ,Accepted 30 August 2009.

References 

  1. Abrams B, Pickett KE. Maternal nutrition. In:  Creasy RK,  Resnik R editor. Maternal–Fetal Medicine. 4th edn.. Philadelphia, PA: W.B. Saunders Company; 1999;p. 122–131
  2. Allaire AD, Ballenger KA, Wells SR, McMohan MJ, Lessey BA. Placental apoptosis in preeclampsia. Obsetet. Gynecol. 2000;96:271–276
  3. Ashkar AA, Di Santo JP, Croy BA. Interferon γ contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy. J. Exp. Med. 2000;192:259–269
  4. Baumann MU, Bersinger NA, Surbek DV. Serum markers for predicting pre-eclampsia. Mol. Aspects Med. 2007;28:227–244
  5. Bulla R, Villa A, Bossi F, Cassetti A, Radillo O, Spessotto P, et al. VE-cadherin is a critical molecule for trophoblast–endothelial cell interaction in decidual spiral arteries. Exp. Cell Res. 2005;303:101–113
  6. Crocker IP, Cooper S, Ong SC, Baker PN. Altered cell kinetics in cultured placental villous explants in pregnancies complicated by preeclampsia and intra-uterine growth restriction. J. Pathol. 2004;204:11–18
  7. Dekker G, Sibai B. Primary, secondary and tertiary prevention of pre-eclampsia. Lancet. 2001;357:209–215
  8. Gagon A, Wilson RD. Obstetrical complications associated with abnormal maternal serum marker analytes. J. Obstet. Gynaecol. Can. 2008;30:918–932
  9. Gilbert JS, Ryan MJ, LaMarca BB, Sedeek M, Murphy SR, Granger JP. Pathophysiology of hypertension during preeclampsia: linking placental ischemia with endothelial dysfunction. Am. J. Physiol. Heart Circ. Physiol. 2008;294:541–550
  10. Girardi G, Redecha P, Salmon JE. Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation. Nat. Med. 2004;10:1222–1226
  11. Girardi G, Yarilin D, Thurman JM, Holers VM, Salmon JE. Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction. J. Exp. Med. 2006;203:2165–2175
  12. Haeger M, Unander M, Norder-Hansson B, Tylman M, Bengtsson A. Complement, neutrophil, and macrophage activation in women with severe preeclampsia and the syndrome of hemolysis, elevated liver enzymes, and low platelet count. Obstet. Gynecol. 1992;79:19–26
  13. Hanna J, Goldman-Wohl D, Hamani Y, Avraham I, Greenfield C, Natanson-Yaron S, et al. Decidual NK cells regulate key developmental processes at the human fetal–maternal interface. Nat. Med. 2006;12:1065–1074
  14. Heazell AEP, Crocker IP. Live and let die-regulation of villous trophoblast apoptosis in normal and abnormal pregnancies. Placenta. 2008;29:772–783
  15. Heitner JC, Koy C, Kreutzer M, Gerber B, Reimer T, Glocker MO. Differentiation of HELLP patients from healthy pregnant women by proteome analysis—on the way towards a clinical marker set. J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci. 2006;840:10–19
  16. Hung TH, Skepper JN, Charnock-Jones SD, Burton GJ. Hypoxia reoxygenation. A potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia. Circ. Res. 2002;90:1274–1281
  17. Issaq HJ, Veenstra TD, Conrads TP, Felschow D. The SELDI-TOF MS approach to proteomics: protein profiling and biomarker identification. Biochem. Biophys. Res. Commun. 2002;292:587–592
  18. Jonsson Y, Rubèr M, Matthiesen L, Berg G, Nieminen K, Sharma S, et al. Cytokine mapping of sera from women with preeclampsia and normal pregnancies. J. Reprod. Immunol. 2006;70:83–91
  19. Kalkunte S, Chichester CO, Gotsch F, Sentman CL, Romero R, Sharma S. Evolution of non-cytotoxic uterine natural killer cells. Am. J. Reprod. Immunol. 2008;59:425–432
  20. Kalkunte S, Lai Z, Tewari N, Chichester C, Romero R, Padbury J, et al. In vitro and in vivo evidence for lack of endovascular remodeling by third trimester trophoblasts. Placenta. 2008;29:871–878
  21. Kalkunte S, Mselle TF, Norris WE, Wira CR, Sentman CL, Sharma S. VEGF C facilitates immune tolerance and endovascular activity of human uterine NK cells at the maternal–fetal interface. J. Immunol. 2009;182:4085–4092
  22. Khong TY, De Wolf F, Robertson WB, Brosens I. Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants. Br. J. Obstet. Gynecol. 1986;93:1049–1059
  23. Kim YM, Bujold E, Chaiworapongsa T, Gomez R, Yoon BH, Thaler HT, et al. Failure of physiologic transformation of the spiral arteries in patients with preterm labor and intact membranes. Am. J. Obstet. Gynecol. 2003;189:1063–1069
  24. Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, et al. Circulating angiogenic factors and the risk of preeclampsia. N. Engl. J. Med. 2004;350:672–683
  25. Levy R, Smith SD, Yusuf K, Huettner PC, Kraus FT, Sadovsky Y, et al. Trophoblasts apoptosis from pregnancies complicated by fetal growth restriction is associated with enhanced p53 expression. Am. J. Obstet. Gynecol. 2002;186:1056–1061
  26. Lynch AM, Murphy JR, Byers T, Gibbs RS, Neville MC, Giclas PC, et al. Alternative complement pathway activation fragment Bb in early pregnancy as a predictor of preeclampsia. Am. J. Obstet. Gynecol. 2008;198(385):e1–e9
  27. Matzuk MM, Burns KH, Viveiros MM, Eppig JJ. Intercellular communication in the mammalian ovary: oocytes carry the conversation. Science. 2002;296:2178–2180
  28. Medawar PB. Some immunological and endocrinological problems raised by the evolution of viviparity in vertebrates. Symp. Soc. Exp. Biol. 1953;7:320–338
  29. Moffett A, Hiby SE. How does the maternal immune system contribute to the development of pre-eclampsia?. Placenta. 2007;28:S51–S56
  30. Mohaupt M. Molecular aspects of preeclampsia. Mol. Aspects Med. 2007;28:169–191
  31. Murphy SP, Fast LD, Hanna NN, Sharma S. Uterine NK cells mediate inflammation-induced fetal demise in IL-10-null mice. J. Immunol. 2005;175:4084–4090
  32. Murphy SP, Hanna NN, Fast LD, Shaw S, Berg G, Padbury JF, et al. Evidence for participation of uterine natural killer cells in the mechanisms responsible for spontaneous preterm labor and delivery. Am. J. Obstet. Gynecol. 2009;200:308, e1-308.e9
  33. Mutter WP, Karumanchi SA. Molecular mechanisms of preeclampsia. Microvasc. Res. 2008;75:1–8
  34. Naicker T, Khedun SM, Moodley J, Pijnenborg R. Quantitative analysis of trophoblast invasion in preeclampsia. Acta Obstet. Gynecol. Scand. 2003;82:722–729
  35. Nevo O, Soleymanlou N, Wu Y, Xu J, Kingdom J, Many A, et al. Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006;355:992–1005
  36. Paria BC, Reese J, Das SK, Dey SK. Deciphering the cross-talk of implantation: advances and challenges. Science. 2002;296:2185–2188
  37. Rampersad R, Barton A, Sadovsky Y, Nelson DM. The C5b-9 membrane attack complex of complement activation localizes to villous trophoblasts injury in vivo and modulates human trophoblast function in vitro. Placenta. 2008;29:855–861
  38. Redman CWG, Sargent IL. Placental debris, oxidative stress and preeclampsia. Placenta. 2000;21:597–602
  39. Report of the national high blood pressure education program working group on high blood pressure in pregnancy, 2000. Am. J. Obstet. Gynecol. 183, S1–S22.
  40. Roberts JM, Hubel CA. Is oxidative stress the link in the two—stage model of preeclampsia. Lancet. 1999;354:788–789
  41. Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet. 2005;365:785–799
  42. Tedesco F, Narchi G, Radillo O, Meri S, Ferrone S, Betterle C. Susceptibility of human trophoblast to killing by human complement and the role of complement regulatory proteins. J. Immunol. 1993;151:1562–1570
  43. Thaxton J, Romero R, Sharma S. TLR-9 activation coupled to IL-10 deficiency induces adverse pregnancy outcomes. J. Immunol. 2009;183:1144–1154
  44. Vatten LJ, Skjaerven R. Is pre-eclampsia more than one disease?. Br. J. Obstet. Gynecol. 2004;111:298–302
  45. Watanabe H, Hamada H, Yamada N, Sohda S, Yamakawa-Kobayashi K, Yoshikawa H, et al. Proteome analysis reveals elevated serum levels of clusterin in patients with preeclampsia. Proteomics. 2004;4:537–543
  46. Zhau Y, Fisher SJ, Janatpor M, Genbacev O, Dejana E, Wheelock M, et al. Human cytotrophoblasts adopt a vascular as they differentiate. A strategy for successful endovascular invasion. J. Clin. Invest. 1997;99:2139–2151

PII: S0165-0378(09)00447-1

doi: 10.1016/j.jri.2009.08.006

Journal of Reproductive Immunology
Volume 83, Issue 1 , Pages 134-138 , December 2009

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