Journal of Reproductive Immunology
Volume 83, Issue 1 , Pages 50-55 , December 2009

Human zona pellucida glycoproteins: functional relevance during fertilization

Received 12 March 2009 ,Revised 1 July 2009 ,Accepted 7 July 2009.

References 

  1. Bansal P, Chakrabarti K, Gupta SK. Functional activity of human ZP3-primary sperm receptor resides towards its C-terminus. Biol. Reprod. 2009;81:7–15
  2. Bausek N, Ruckenbauer HH, Pfeifer S, Schneider WJ, Wohlrab F. Interaction of sperm with purified native chicken ZP1 and ZPC proteins. Biol. Reprod. 2004;71:684–690
  3. Beebe SJ, Leyton L, Burks D, Ishikawa M, Fuerst T, Dean J, et al. Recombinant mouse ZP3 inhibits sperm binding and induces the acrosome reaction. Dev. Biol. 1992;151:48–54
  4. Bleil JD, Wassarman PM. Mammalian sperm–egg interaction: identification of a glycoprotein in mouse egg zonae pellucidae possessing receptor activity for sperm. Cell. 1980;20:873–882
  5. Bleil JD, Greve JM, Wassarman PM. Identification of a secondary sperm receptor in the mouse egg zona pellucida: role in maintenance of binding of acrosome-reacted sperm to eggs. Dev. Biol. 1988;128:376–385
  6. Bork P, Sander C. A large domain common to sperm receptors (Zp2 and Zp3) and TGF-beta type III receptor. FEBS Lett. 1992;300:237–240
  7. Bookbinder LH, Cheng A, Bleil JD. Tissue- and species-specific expression of sp56, a mouse sperm fertilization protein. Science. 1995;269:86–89
  8. Bray C, Son JH, Meizel S. A nicotinic acetylcholine receptor is involved in the arosome reaction of human sperm initiated by recombinant human ZP3. Biol. Reprod. 2002;67:782–788
  9. Bray C, Son JH, Kumar P, Harris JD, Meizel S. A role for the human sperm glycine receptor/Cl channel in the acrosome reaction initiated by recombinant ZP3. Biol. Reprod. 2002;66:91–97
  10. Brewis IA, Clayton R, Barratt CL, Hornby DP, Moore HD. Recombinant human zona pellucida glycoprotein 3 induces calcium influx and acrosome reaction in human spermatozoa. Mol. Hum. Reprod. 1996;2:583–589
  11. Bukovsky A, Gupta SK, Bansal P, Chakravarty S, Chaudhary M, Svetlikova M, et al. Production of monoclonal antibodies against recombinant human zona pellucida glycoproteins: utility in immunolocalization of respective zona proteins in ovarian follicles. J. Reprod. Immunol. 2008;78:102–114
  12. Burks DJ, Carballada R, Moore HD, Saling PM. Interaction of a tyrosine kinase from human sperm with the zona pellucida at fertilization. Science. 1995;269:83–86
  13. Caballero-Campo P, Chirinos M, Fan XJ, González-González ME, Galicia-Chavarría M, Larrea F, et al. Biological effects of recombinant human zona pellucida proteins on sperm function. Biol. Reprod. 2006;74:760–768
  14. Chakravarty S, Suraj K, Gupta SK. Baculovirus-expressed recombinant human zona pellucida glycoprotein-B induces acrosomal exocytosis in capacitated spermatozoa in addition to zona pellucida glycoprotein-C. Mol. Hum. Reprod. 2005;11:365–372
  15. Chakravarty S, Kadunganattil S, Bansal P, Sharma RK, Gupta SK. Relevance of glycosylation of human zona pellucida glycoproteins for their binding to capacitated human spermatozoa and subsequent induction of acrosomal exocytosis. Mol. Reprod. Dev. 2008;75:75–88
  16. Chamberlin ME, Dean J. Human homolog of the mouse sperm receptor. Proc. Natl. Acad. Sci. U.S.A. 1990;87:6014–6018
  17. Chapman N, Kessopoulou E, Andrews P, Hornby D, Barratt CR. The polypeptide backbone of recombinant human zona pellucida glycoprotein-3 initiates acrosomal exocytosis in human spermatozoa in vitro. Biochem. J. 1998;330:839–845
  18. Chiu PC, Wong BS, Lee CL, Pang RT, Lee KF, Sumitro SB, et al. Native human zona pellucida glycoproteins: purification and binding properties. Hum. Reprod. 2008;23:1385–1393
  19. Chiu PC, Wong BS, Chung MK, Lam KK, Pang RT, Lee KF, et al. Effects of native human zona pellucida glycoproteins 3 and 4 on acrosome reaction and zona pellucida binding of human spermatozoa. Biol. Reprod. 2008;79:869–877
  20. Cross NL, Morales P, Overstreet JW, Hanson FW. Induction of acrosome reactions by the human zona pellucida. Biol. Reprod. 1988;38:235–244
  21. Dong KW, Chi TF, Juan YW, Chen CW, Lin Z, Xiang XQ, et al. Characterization of the biologic activities of a recombinant human zona pellucida protein 3 expressed in human ovarian teratocarcinoma (PA-1) cells. Am. J. Obstet. Gynecol. 2001;184:835–843
  22. Ensslin MA, Shur BD. Identification of mouse sperm SED1, a bimotif EGF repeat and discoidin-domain protein involved in sperm–egg binding. Cell. 2003;22:405–417
  23. Govind CK, Gahlay GK, Choudhury S, Gupta SK. Purified and refolded recombinant bonnet monkey (Macaca radiata) zona pellucida glycoprotein-B expressed in Escherichia coli binds to spermatozoa. Biol. Reprod. 2001;64:1147–1152
  24. Greve JM, Wassarman PM. Mouse egg extracellular coat is a matrix of interconnected filaments possessing a structural repeat. J. Mol. Biol. 1985;181:253–264
  25. Harris JD, Hibler DW, Fontenot GK, Hsu KT, Yurewicz EC, Sacco AG. Cloning and characterization of zona pellucida genes and cDNAs from a variety of mammalian species: the ZPA, ZPB and ZPC gene families. DNA Sequence. 1994;4:361–393
  26. Hughes DC, Barratt CL. Identification of the true human orthologue of the mouse Zp1 gene: evidence for greater complexity in the mammalian zona pellucida?. Biochim. Biophys. Acta. 1999;1447:303–306
  27. Jimenez-Movilla M, Aviles M, Gomez-Torres MJ, Fernandez-Colom PJ, Castells MT, de Juan J, et al. Carbohydrate analysis of the zona pellucida and cortical granules of human oocytes by means of ultrastructural cytochemistry. Hum. Reprod. 2004;19:1842–1855
  28. Jovine L, Qi H, Williams Z, Litscher E, Wassarman PM. The ZP domain is a conserved module for polymerization of extracellular proteins. Nat. Cell. Biol. 2002;4:457–461
  29. Jovine L, Darie CC, Litscher ES, Wassarman PM. Zona pellucida domain proteins. Annu. Rev. Biochem. 2005;74:83–114
  30. Jovine L, Janssen WG, Litscher ES, Wassarman PM. The PLAC1-homology region of the ZP domain is sufficient for protein polymerisation. BMC Biochem. 2006;7:11
  31. Lee MA, Check JH, Kopf GS. A guanine nucleotide-binding regulatory protein in human sperm mediates acrosomal exocytosis induced by the human zona pellucida. Mol. Reprod. Dev. 1992;31:78–86
  32. Liang LF, Dean J. Conservation of mammalian secondary sperm receptor genes enables the promoter of the human gene to function in mouse oocytes. Dev. Biol. 1993;156:399–408
  33. Maymon BB, Maymon R, Ben-Nun I, Ghetler Y, Shalgi R, Skutelsky E. Distribution of carbohydrates in the zona pellucida of human oocytes. J. Reprod. Fertil. 1994;102:81–86
  34. Monne M, Han L, Schwend T, Burendahl S, Jovine L. Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats. Nature. 2008;456:653–657
  35. Miller DJ, Macek MB, Shur BD. Complementarity between sperm surface beta-1,4-galactosyltransferase and egg-coat ZP3 mediates sperm–egg binding. Nature. 1992;357:589–593
  36. Ni Y, Li K, Xu W, Song L, Yao K, Zhang X, et al. Acrosome reaction induced by recombinant human zona pellucida 3 peptides rhuZP3a22 approximately 176 and rhuZP3b177 approximately 348 and their mechanism. J. Androl. 2007;28:381–388
  37. Qi H, Williams Z, Wassarman PM. Secretion and assembly of zona pellucida glycoproteins by growing mouse oocytes microinjected with epitope-tagged cDNAs for mZP2 and mZP3. Mol. Biol. Cell. 2002;13:530–541
  38. Schuffner AA, Bastiaan HS, Duran HE, Lin ZY, Morshedi M, Franken DR, et al. Zona pellucida-induced acrosome reaction in human sperm: dependency on activation of pertussis toxin-sensitive Gi protein and extracellular calcium, and priming effect of progesterone and follicular fluid. Mol. Hum. Reprod. 2002;8:722–727
  39. Thim L. A new family of growth factor-like peptides. ‘Trefoil’ disulphide loop structures as a common feature in breast cancer associated peptide (pS2), pancreatic spasmolytic polypeptide (PSP), and frog skin peptides (spasmolysins). FEBS Lett. 1989;250:85–90
  40. Tsubamoto H, Hasegawa A, Nakata Y, Naito S, Yamasaki N, Koyama K. Expression of recombinant human zona pellucida protein 2 and its binding capacity to spermatozoa. Biol. Reprod. 1999;61:1649–1654
  41. van Duin M, Polman JE, De Breet IT, van Ginneken K, Bunschoten H, Grootenhuis A, et al. Recombinant human zona pellucida protein ZP3 produced by Chinese hamster ovary cells induces the human sperm acrosome reaction and promotes sperm–egg fusion. Biol. Reprod. 1994;51:607–617
  42. Wassarman PM, Litscher ES. Mammalian fertilization: the egg's multifunctional zona pellucida. Int. J. Dev. Biol. 2008;52:665–676
  43. Yanagimachi R. In:  Knobil E,  Neill JD editor. The Physiology of Reproduction. Vol.1:New York: Raven; 1994;p. 189–317
  44. Zhao M, Gold L, Ginsberg AM, Liang LF, Dean J. Conserved furin cleavage site not essential for secretion and integration of ZP3 into the extracellular egg coat of transgenic mice. Mol. Cell. Biol. 2002;22:3111–3120
  45. Zhao M, Boja ES, Hoodbhoy T, Nawrocki J, Kaufman JB, Kresge N, et al. Mass spectrometry analysis of recombinant human ZP3 expressed in glycosylation-deficient CHO cells. Biochemistry. 2004;43:12090–12104

PII: S0165-0378(09)00446-X

doi: 10.1016/j.jri.2009.07.008

Journal of Reproductive Immunology
Volume 83, Issue 1 , Pages 50-55 , December 2009