Journal of Reproductive Immunology
Volume 82, Issue 2 , Pages 142-147 , November 2009

Effector functions of human decidual NK cells in healthy early pregnancy are dependent on the specific engagement of natural cytotoxicity receptors

  • Hicham El Costa

      Affiliations

    • Institut National de la Santé et de la Recherche Médicale, U563, Toulouse, F-31300, France
    • Université Paul Sabatier, Toulouse, F-31077, France
    • ,
  • Julie Tabiasco

      Affiliations

    • Institut National de la Santé et de la Recherche Médicale, U563, Toulouse, F-31300, France
    • Université Paul Sabatier, Toulouse, F-31077, France
    • ,
  • Alain Berrebi

      Affiliations

    • Institut National de la Santé et de la Recherche Médicale, U563, Toulouse, F-31300, France
    • Centre Hospitalo-Universitaire, Service de Gynécologie-Obstétrique, Hôpital Paule de Viguier, Toulouse, F-31059, France
    • ,
  • Olivier Parant

      Affiliations

    • Institut National de la Santé et de la Recherche Médicale, U563, Toulouse, F-31300, France
    • Centre Hospitalo-Universitaire, Service de Gynécologie-Obstétrique, Hôpital Paule de Viguier, Toulouse, F-31059, France
    • ,
  • Maryse Aguerre-Girr

      Affiliations

    • Institut National de la Santé et de la Recherche Médicale, U563, Toulouse, F-31300, France
    • Université Paul Sabatier, Toulouse, F-31077, France
    • ,
  • Marie-Pierre Piccinni

      Affiliations

    • Centre of Excellence for Research, Transfer and High Education DENOTHE, University of Florence and Department of Internal Medicine, 50134 Florence, Italy
    • ,
  • Philippe Le Bouteiller

      Affiliations

    • Institut National de la Santé et de la Recherche Médicale, U563, Toulouse, F-31300, France
    • Université Paul Sabatier, Toulouse, F-31077, France
    • Centre Hospitalo-Universitaire, Service de Gynécologie-Obstétrique, Hôpital Paule de Viguier, Toulouse, F-31059, France
    • Corresponding Author InformationCorresponding author. Tel.: +33 562 748 374; fax: +33 562 744 558.

Received 2 April 2009 ,Revised 27 May 2009 ,Accepted 5 June 2009.

References 

  1. Bryceson YT, March ME, Ljunggren HG, Long EO. Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion. Blood. 2006;107:159–166
  2. Bulmer J, Lash G. Human uterine natural killer cells: a reappraisal. Mol. Immunol. 2005;42:511–521
  3. Bulmer JN, Morrison L, Longfellow M, Ritson A, Pace D. Granulated lymphocytes in human endometrium: histochemical and immunohistochemical studies. Hum. Reprod. 1991;6:791–798
  4. El Costa H, Casemayou A, Aguerre-Girr M, Rabot M, Berrebi A, Parant O, et al. Critical and differential roles of NKp46- and NKp30-activating receptors expressed by uterine NK cells in early pregnancy. J. Immunol. 2008;181:3009–3017
  5. Hanna J, Goldman-Wohl D, Hamani Y, Avraham I, Greenfield C, Natanson-Yaron S, et al. Decidual NK cells regulate key developmental processes at the human fetal–maternal interface. Nat. Med. 2006;12:1065–1074
  6. Ho JW, Hershkovitz O, Peiris M, Zilka A, Bar-Ilan A, Nal B, et al. H5-type influenza virus hemagglutinin is functionally recognized by the natural killer-activating receptor NKp44. J. Virol. 2008;82:2028–2032
  7. King A. Uterine leukocytes and decidualization. Hum. Reprod. Update. 2000;6:28–36
  8. King A, Allan D, Bowen M, Powis S, Joseph S, Verma S, et al. HLA-E is expressed on trophoblast and interacts with CD94/NKG2 receptors on decidual NK cells. Eur. J. Immunol. 2000;30:1623–1631
  9. Koopman L, Kopcow H, Rybalov B, Boyson J, Orange J, Schatz F, et al. Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential. J. Exp. Med. 2003;198:1201–1212
  10. Kopcow HD, Allan DS, Chen X, Rybalov B, Andzelm MM, Ge B, et al. Human decidual NK cells form immature activating synapses and are not cytotoxic. Proc. Natl. Acad. Sci. U.S.A. 2005;102:15563–15568
  11. Le Bouteiller P, Sargent I. HLA class I molecules in the placenta: which ones? Where? and what for? A workshop report. Placenta. 2000;21(Suppl. A):S93–S96
  12. Le Bouteiller P, Tabiasco J. Killers become builders during pregnancy. Nat. Med. 2006;12:991–992
  13. Manaster I, Mizrahi S, Goldman-Wohl D, Sela HY, Stern-Ginossar N, Lankry D, et al. Endometrial NK cells are special immature cells that await pregnancy. J. Immunol. 2008;181:1869–1876
  14. Moffett-King A. Natural killer cells and pregnancy. Nat. Rev. Immunol. 2002;2:656–663
  15. Moffett A, Loke C. Immunology of placentation in eutherian mammals. Nat. Rev. Immunol. 2006;6:584–594
  16. Pereira L, Maidji E, McDonagh S, Tabata T. Insights into viral transmission at the uterine–placental interface. Trends Microbiol. 2005;13:164–174
  17. Poggi A, Prevosto C, Massaro AM, Negrini S, Urbani S, Pierri I, et al. Interaction between human NK cells and bone marrow stromal cells induces NK cell triggering: role of NKp30 and NKG2D receptors. J. Immunol. 2005;175:6352–6360
  18. Riley JK, Yokoyama WM. NK cell tolerance and the maternal–fetal interface. Am. J. Reprod. Immunol. 2008;59:371–387
  19. Saito S, Nakashima A, Myojo-Higuma S, Shiozaki A. The balance between cytotoxic NK cells and regulatory NK cells in human pregnancy. J. Reprod. Immunol. 2008;77:14–22
  20. Sharkey AM, Gardner L, Hiby S, Farrell L, Apps R, Masters L, et al. Killer Ig-like receptor expression in uterine NK cells is biased toward recognition of HLA-C and alters with gestational age. J. Immunol. 2008;181:39–46
  21. Trowsdale J, Moffett A. NK receptor interactions with MHC class I molecules in pregnancy. Semin. Immunol. 2008;20:317–320
  22. Vales-Gomez M, Reyburn H, Erskine R, Lopez-Botet M, Strominger JL. Kinetics and peptide dependency of the binding of the inhibitory NK receptor CD94/NKG2-A and the activating receptor CD94/NKG2-C to HLA-E. Embo. J. 1999;18:4250–4260
  23. Vivier E, Tomasello E, Baratin M, Walzer T, Ugolini S. Functions of natural killer cells. Nat. Immunol. 2008;9:503–510

PII: S0165-0378(09)00250-2

doi: 10.1016/j.jri.2009.06.123

Journal of Reproductive Immunology
Volume 82, Issue 2 , Pages 142-147 , November 2009

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