Received 20 January 2009; received in revised form 20 April 2009; accepted 1 May 2009. published online 26 June 2009.
Abstract
There are abundant theories in the scientific literature that propose a range of pathophysiological pathways for preeclampsia. In this review we discuss some of the contributions made to this field from the perspective of a placental developmental biology laboratory. We discuss an underlying immune component of preeclampsia associated with expression of HLA-G and also a beneficial function of decidual NK cells. We conclude by summarizing newer findings regarding the anti-angiogenic expression of soluble fms-like tyrosine kinase (sFlt-1) and its role in the development of preeclampsia.
Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Centers, Mt. Scopus, Jerusalem, Israel
Corresponding author at: Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Centers, PO Box 24035, Mt. Scopus, Jerusalem, Israel. Tel.: +972 2 5844111; fax: +972 2 5815370.
ABSTRACT