Journal of Reproductive Immunology
Volume 82, Issue 2 , Pages 96-99, November 2009

Preeclampsia—a placenta developmental biology perspective

  • Debra Goldman-Wohl

      Affiliations

    • Corresponding Author InformationCorresponding author at: Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Centers, PO Box 24035, Mt. Scopus, Jerusalem, Israel. Tel.: +972 2 5844111; fax: +972 2 5815370.
    • ,
  • Simcha Yagel

Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Centers, Mt. Scopus, Jerusalem, Israel

Received 20 January 2009; received in revised form 20 April 2009; accepted 1 May 2009. published online 26 June 2009.

Abstract 

There are abundant theories in the scientific literature that propose a range of pathophysiological pathways for preeclampsia. In this review we discuss some of the contributions made to this field from the perspective of a placental developmental biology laboratory. We discuss an underlying immune component of preeclampsia associated with expression of HLA-G and also a beneficial function of decidual NK cells. We conclude by summarizing newer findings regarding the anti-angiogenic expression of soluble fms-like tyrosine kinase (sFlt-1) and its role in the development of preeclampsia.

Keywords: Preeclampsia, HLA-G, Decidua, NK cell, sFlt

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PII: S0165-0378(09)00097-7

doi:10.1016/j.jri.2009.05.002

Journal of Reproductive Immunology
Volume 82, Issue 2 , Pages 96-99, November 2009

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