Journal of Reproductive Immunology
Volume 82, Issue 2 , Pages 112-118 , November 2009

hCG and hyperglycosylated hCG in the establishment and evolution of hemochorial placentation

Received 17 December 2008 ,Revised 17 April 2009 ,Accepted 20 April 2009.

References 

  1. Amano J, Nishimura R, Mochizuki M, Kobata A. Comparative study of the mucin-type sugar chains of human chorionic gonadotropin present in the urine of patients with trophoblastic diseases and healthy pregnant women. J. Biol. Chem. 1988;263:1157–1165
  2. Bahado-Singh RO, Oz AU, Kingston JM, Shahabi S, Hsu CD, Cole LA. The role of hyperglycosylated hCG in trophoblast invasion and the prediction of subsequent preeclampsia. Prenat. Diagn. 2002;22:478–483
  3. Bambra CS. Purification and properties of baboon chorionic gonadotrophin. J. Reprod. Fertil. 1987;19:421–430
  4. Burton GJ. Early placental development. Placenta. 2006;27:A2
  5. Burton GJ. Placental oxidative stress: from miscarriage to preeclampsia. J. Soc. Gynecol. Invest. 2004;11:342–352
  6. Cole LA, Butler SA, Khanlian SA, Giddings A, Muller CY, Seckl MJ, et al. Gestational trophoblastic diseases: 2. Hyperglycosylated hCG as a reliable marker of active neoplasia. Gynecol. Oncol. 2006;102:150–158
  7. Cole LA, Khanlian SA, Riley JM, Butler SA. Hyperglycosylated hCG in gestational implantation and in choriocarcinoma and testicular germ cell malignancy tumorigenesis. J. Reprod. Med. 2006;51:915–919
  8. Cole LA, Sutton JM, Higgins TNH, Cembrowski GS. Between-method variation in hCG test results. Clin. Chem. 2004;50:874–882
  9. Cole LA, Dai D, Butler SA, Leslie KK, Kohorn EI. Gestational trophoblastic diseases: 1. Pathophysiology of hyperglycosylated hCG-regulated neoplasia. Gynecol. Oncol. 2006;102:144–149
  10. Cole LA. The O-linked oligosaccharide structures are strikingly different on pregnancy and choriocarcinoma hCG. J. Clin. Endocrinol. Metab. 1987;65:811–813
  11. Cole LA, Khanlian SA, Kohorn EI. Evolution of the human brain, chorionic gonadotropin and hemochorial implantation of the placenta: insights into origins of pregnancy failures, preeclampsia and choriocarcinoma. J. Reprod. Med. 2008;53:449–557
  12. Cole LA, Sutton JM, Stephens ND. Invasive trophoblast antigen (ITA): a new high-sensitivity test for detecting gestational Down syndrome. J. Clin. Ligand Assay. 2003;26:23–28
  13. Crawford RJ, Traeger GW, Niall HD. The nucleotide sequence of baboon chorionic gonadotropin beta-subunit genes have diverged from the human. Gene. 1986;46:161–169
  14. Cunnane SC, Herbige LS, Crawford MA. The importance of energy and nutrient supply in human brain evolution. Nutr. Health. 1993;9:19–35
  15. Elliott MM, Kardana A, Lustbader JW, Cole LA. Carbohydrate and peptide structure of the α- and β-subunits of human chorionic gonadotropin from normal and aberrant pregnancy and choriocarcinoma. Endocrine. 1997;7:15–32
  16. Fiddes JC, Goodman HM. The cDNA for the β-subunit of human chorionic gonadotropin suggests evolution of a gene by read through into the 3′-untranslated region. Nature. 1980;286:684–687
  17. Gibbons A. Solving the brain's energy crisis. Science. 1998;280:1345–1347
  18. Hamade AL, Nakabayashi K, Sato A, Kiyoshi K, Takamatsu Y, Laoag-Fernandez JB, et al. Transfection of antisense chorionic gonadotropin β gene into choriocarcinoma cells suppresses the cell proliferation and induces apoptosis. J. Clin. Endocrinol. Metab. 2005;90:4873–4879
  19. Handschuh K, Guibourdenche J, Tsatsaris V, Guesnon M, Laurendeau I, Evain-Brion D, et al. Human chorionic gonadotropin produced by the invasive trophoblast but not the villous trophoblast promotes cell invasion and is down-regulated by peroxisome proliferator-activated receptor-a. Endocrinology. 2007;148:5011–5019
  20. Handschuh K, Guibourdenche J, Tsatsaris V, Guesnon M, Laurendeau I, Evain-Brion D, et al. Human chorionic gonadotropin expression in human trophoblasts from early placenta: comparative study between villous and entravillous trophoblastic cells. Placenta. 2007;28:175–184
  21. Herr F, Baal N, Reisinger K, Lorenz A, McKinnon T, Preissner KT, et al. hCG in the regulation of placental angiogenesis. Results of an in vitro study. Placenta. 2007;28(Suppl. A):85–93
  22. Hirose T. Exogenous stimulation of corpus luteum formation in the rabbit: influence of extracts of human placenta, decidua, fetus, hydatid mole, and corpus luteum on the rabbit gonad. J. Jpn. Gynecol. Soc. 1920;16:1055
  23. Jameson LJ, Hollenberg AN. Regulation of chorionic gonadotropin gene expression. Endocr. Rev. 1993;14:203–220
  24. Jauniauz E, Poston L, Burton GJ. Placental-related diseases of pregnancy: involvement of oxidative stress and implications in human evolution. Human Reprod. Updation. 2006;12:747–755
  25. Jordaan HVF. Newborn brain: body weight ratios. Am. J. Phys. Anthropol. 2005;44:2279–2284
  26. Kennedy TG, Gillio-Meina C, Phang SH. Prostaglandins and the initiation of blastocyst implantation and decidualization. Reproduction. 2007;134:635–643
  27. Kliman HJ. Uteroplacental blood flow. The story of decidualization, menstruation, and trophoblast invasion. Am. J. Path. 2000;157:1759–1768
  28. Kovalevskaya G, Genbacev O, Fisher SJ, Cacere E, O’Connor JF. Trophoblast origin of hCG isoforms: cytotrophoblasts are the primary source of choriocarcinoma-like hCG. Mol. Cell. Endocrinol. 2002;194:147–155
  29. Lei ZM, Reshef E, Rao CV. The expression of human chorionic gonadotropin/luteinizing hormone receptors in human endometrial and myometrial blood vessels. J. Clin. Endocrinol. Metab. 1992;75:651–659
  30. Lei ZM, Rao CV. Gonadotropin receptors in human fetoplacental unit: implications for hCG as an intracrine, paracrine, and endocrine regulator of human fetoplacental function. Trophoblast Res. 1992;6:213–224
  31. Lei ZM, Rao CV, Kornyei J, Licht P, Hiatt ES. Novel expression of human chorionic gonadotropin/luteinizing hormone receptor gene in brain. Endocrinology. 1993;132:2262–2270
  32. Lei ZM, Taylor DD, Gercel-Taylor C, Rao CV. Human chorionic gonadotropin promotes tumorigenesis of choriocarcinoma JAr cells. Trophoblast Res. 1999;13:147–159
  33. Luckett WP. Comparative development and evolution of the placenta in primates. Contrib. Primatol. 1974;3:142–234
  34. Martin RD. Relative brain size and basal metabolic rate in terrestrial vertebrates. Nature. 1981;293:57–60
  35. Martin RD. Scaling of the mammalian barrier: the maternal energy hypothesis. News Physiol. Sci. 1996;4:149–154
  36. Martin RD. Human reproduction: a comparative background for medical hypotheses. J. Reprod. Immunol. 2003;59:111–135
  37. Maston GA, Ruvolo M. Chorionic gonadotropin has a recent origin within primates and an evolutionary history of selection. Mol. Biol. Evol. 2002;19:320–334
  38. Nisula BC, Wehmann RE. Distribution, metabolism, and excretion of human chorionic gonadotropin and its subunits in man. In:  Segal SJ editors. Chorionic Gonadotropin. New York: Plenum Press; 1980;p. 199–212
  39. Pijnenborg R. The placental bed. Hypertens. Pregn. 1996;15:7–23
  40. Rao CV, Alsip NL. Use of the rat model to study hCG/LH effects on uterine blood flow. Semin. Reprod. Med. 2001;19:75–85
  41. Robillard PY, Chaline J, Chaouat G, Hulsey TC. Preeclampsia/eclampsia and the evolution of the human brain. Curr. Anthropol. 2003;44:130–135
  42. Robillard PY, Hulset TC, Deka CG. Preeclampsia and human reproduction. An essay of a long term reflection. J. Reprod. Immunol. 2003;59:93–100
  43. Sasaki Y, Ladner DG, Khanlian SA, Cole LA. Hyperglycosylated hCG and the source of pregnancy failures. Fertil. Steril. 2008;89:1786–1871
  44. Shi QJ, Lei ZM, Rao CV, Lin J. Novel role of human chorionic gonadotropin in differentiation of human cytotrophoblasts. Endocrinology. 1993;132:1387–1395
  45. Suginami H, Yano M, Hamada K, Ito T, Yano K, Matsuura S. Qualitative and quantitative differences in hLH species in the first and second LH release induced by continuous stimulation with synthetic LHRH in normal menstrual cycle as assessed by isoelectrofocusing. Endocrinol. Japonica. 1985;32:583–593
  46. Sutton JM, Cole LA. Sialic acid-deficient invasive trophoblast antigen (sd-ITA): a new urinary variant for gestational Down syndrome screening. Prenat. Diagn. 2004;24:194–197
  47. Tarrade A, Kuen RL, Malassine A, Tricottet V, Blain P, Vidaud M, et al. Characterization of human villous and extravillous trophoblasts isolated from first trimester placenta. Lab. Invest. 2001;81:1199–1211
  48. Toth P, Lukacs H, Gimes G, Sebestyen A, Pasztor N, Paulin F, et al. Clinical importance of vascular LH/hCG receptors—a review. Reprod. Biol. 2001;1:5–11
  49. Wilmut I, Sales DL, Ashworth CJ. Maternal and embryonic factors associated with prenatal loss in mammals. J. Reprod. Fertil. 1986;76:51–864
  50. Wu H, Lustbader JW, Liu Y, Canfield RE, Hendrickson WA. Structure of human chorionic gonadotropin at 2.6Å resolution from MAD analysis of the selenomethionyl protein. Structure. 1994;2:545–558
  51. Zygmunt M, Herr F, Munstedt K, Lang U, Liang O. Angiogenesis and vasculogenesis in pregnancy. Euro. J. Obstet. Gynecol. Reprod. Biol. 2003;110(Suppl. 1):10–18
  52. Zygmunt M, Herr F, Keller-Schoenwetter S, Kunzi-Rapp K, Munstedt K, Rao CV, et al. Characterization of human chorionic gonadotropin as a novel angiogenic factor. J. Clin. Endocrinol. Metab. 2002;87:5290–5296

PII: S0165-0378(09)00093-X

doi: 10.1016/j.jri.2009.04.007

Journal of Reproductive Immunology
Volume 82, Issue 2 , Pages 112-118 , November 2009

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