Journal of Reproductive Immunology
Volume 78, Issue 2 , Pages 172-180 , July 2008

Correlations of selected vaginal cytokine levels with pregnancy-related traits in women with bacterial vaginosis and mycoplasmas

  • Kelli K. Ryckman

      Affiliations

    • Department of Medicine, Vanderbilt University, Nashville, TN, USA
    • Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232, USA
    • ,
  • Scott M. Williams

      Affiliations

    • Department of Medicine, Vanderbilt University, Nashville, TN, USA
    • Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232, USA
    • Corresponding Author InformationCorresponding author at: Center for Human Genetics Research, Vanderbilt University, 519 Light Hall, Nashville, TN 37232, USA. Tel.: +1 615 322 8036; fax: +1 615 343 8619.
    • ,
  • Jaroslaw Kalinka

      Affiliations

    • Medical and Environmental Pregnancy Health Hazards Unit, Department of Perinatology, I Chair of Gynecology and Obstetrics, Medical University of Lodz, Poland

Received 18 July 2007 ,Revised 6 November 2007 ,Accepted 14 February 2008.

References 

  1. Asselbergs FW, Williams SM, Hebert PR, et al. Gender-specific correlations of plasminogen activator inhibitor-1 and tissue plasminogen activator levels with cardiovascular disease-related traits. J. Thromb. Haemost. 2007;5:313–320
  2. Carey JC, Blackwelder WC, Nugent RP, et al. Antepartum cultures for Ureaplasma urealyticum are not useful in predicting pregnancy outcome. The Vaginal Infections and Prematurity Study Group. Am. J. Obstet. Gynecol. 1991;164:728–733
  3. Cassell GH, Waites KB, Watson HL, et al. Ureaplasma urealyticum intrauterine infection: role in prematurity and disease in newborns. Clin. Microbiol. Rev. 1993;6:69–87
  4. Cauci S, Guaschino S, De AD, et al. Interrelationships of interleukin-8 with interleukin-1beta and neutrophils in vaginal fluid of healthy and bacterial vaginosis-positive women. Mol. Hum. Reprod. 2003;9:53–58
  5. Di RL, Bigioni M, Del GV, et al. Interleukin-1 (IL-1) receptor antagonist gene polymorphism in normal weight obese syndrome: relationship to body composition and IL-1 alpha and beta plasma levels. Pharmacol. Res. 2007;55:131–138
  6. Doh K, Barton PT, Korneeva I, et al. Differential vaginal expression of interleukin-1 system cytokines in the presence of Mycoplasma hominis and Ureaplasma urealyticum in pregnant women. Infect. Dis. Obstet. Gynecol. 2004;12:79–85
  7. Donders GG, Vereecken A, Bosmans E, et al. Vaginal cytokines in normal pregnancy. Am. J. Obstet. Gynecol. 2003;189:1433–1438
  8. Goldenberg RL, Klebanoff MA, Nugent R, et al. Bacterial colonization of the vagina during pregnancy in four ethnic groups. Vaginal Infections and Prematurity Study Group. Am. J. Obstet. Gynecol. 1996;174:1618–1621
  9. Gonzalez BE, Gene A, Ferrer I, et al. Value of endocervical ureaplasma species colonization as a marker of preterm delivery. Gynecol. Obstet. Invest. 2006;61:119–123
  10. Hill GB. The microbiology of bacterial vaginosis. Am. J. Obstet. Gynecol. 1993;169:450–454
  11. Hillier SL, Nugent RP, Eschenbach DA, et al. Association between bacterial vaginosis and preterm delivery of a low-birth-weight infant. The Vaginal Infections and Prematurity Study Group. N. Engl. J. Med. 1995;333:1737–1742
  12. Imseis HM, Greig PC, Livengood CH, et al. Characterization of the inflammatory cytokines in the vagina during pregnancy and labor and with bacterial vaginosis. J. Soc. Gynecol. Invest. 1997;4:90–94
  13. Kelso A. Cytokines: principles and prospects. Immunol. Cell Biol. 1998;76:300–317
  14. Koumans EH, Kendrick JS. Preventing adverse sequelae of bacterial vaginosis: a public health program and research agenda. Sex. Transm. Dis. 2001;28:292–297
  15. Kurki T, Sivonen A, Renkonen OV, et al. Bacterial vaginosis in early pregnancy and pregnancy outcome. Obstet. Gynecol. 1992;80:173–177
  16. Martius J, Eschenbach DA. The role of bacterial vaginosis as a cause of amniotic fluid infection, chorioamnionitis and prematurity—a review. Arch. Gynecol. Obstet. 1990;247:1–13
  17. Mattsby-Baltzer I, Platz-Christensen JJ, Hosseini N, et al. IL-1beta, IL-6, TNFalpha, fetal fibronectin, and endotoxin in the lower genital tract of pregnant women with bacterial vaginosis. Acta Obstet. Gynecol. Scand. 1998;77:701–706
  18. Meis PJ, Goldenberg RL, Mercer BM, et al. The preterm prediction study: risk factors for indicated preterm births. Maternal-Fetal Medicine Units Network of the National Institute of Child Health and Human Development. Am. J. Obstet. Gynecol. 1998;178:562–567
  19. Perni SC, Vardhana S, Korneeva I, et al. Mycoplasma hominis and Ureaplasma urealyticum in mid-trimester amniotic fluid: association with amniotic fluid cytokine levels and pregnancy outcome. Am. J. Obstet. Gynecol. 2004;191:1382–1386
  20. Platz-Christensen JJ, Mattsby-Baltzer I, Thomsen P, et al. Endotoxin and interleukin-1 alpha in the cervical mucus and vaginal fluid of pregnant women with bacterial vaginosis. Am. J. Obstet. Gynecol. 1993;169:1161–1166
  21. Reilly SL, Ferrell RE, Sing CF. The gender-specific apolipoprotein E genotype influence on the distribution of plasma lipids and apolipoproteins in the population of Rochester MN. III. Correlations and covariances. Am. J. Hum. Genet. 1994;55:1001–1018
  22. Sall, J., Creighton, L., Lehman, A., 2005. JMP® Start Statistics.
  23. Silver HM, Sperling RS, St Clair PJ, et al. Evidence relating bacterial vaginosis to intraamniotic infection. Am. J. Obstet. Gynecol. 1989;161:808–812
  24. Spiegel CA, Amsel R, Holmes KK. Diagnosis of bacterial vaginosis by direct gram stain of vaginal fluid. J. Clin. Microbiol. 1983;18:170–177
  25. Sturm-Ramirez K, Gaye-Diallo A, Eisen G, et al. High levels of tumor necrosis factor-alpha and interleukin-1beta in bacterial vaginosis may increase susceptibility to human immunodeficiency virus. J. Infect. Dis. 2000;182:467–473
  26. Taylor-Robinson D. The role of mycoplasmas in pregnancy outcome. Best Pract. Res. Clin. Obstet. Gynaecol. 2007;21:425–438
  27. Usui R, Ohkuchi A, Matsubara S, et al. Vaginal lactobacilli and preterm birth. J. Perinat. Med. 2002;30:458–466
  28. Wasiela M, Brzezinska-Blaszczyk E, Krzeminski Z, et al. Impact of Mycoplasma hominis and Ureaplasma urealyticum on the concentration of proinflammatory cytokines in vaginal fluid. Med. Dosw. Mikrobiol. 2004;56:371–376
  29. Wasiela M, Krzeminski Z, Kalinka J, et al. Correlation between levels of selected cytokines in cervico-vaginal fluid of women with abnormal vaginal bacterial flora. Med. Dosw. Mikrobiol. 2005;57:327–333
  30. Yudkin JS, Stehouwer CD, Emeis JJ, et al. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?. Arterioscler. Thromb. Vasc. Biol. 1999;19:972–978

PII: S0165-0378(08)00026-0

doi: 10.1016/j.jri.2008.02.001

Journal of Reproductive Immunology
Volume 78, Issue 2 , Pages 172-180 , July 2008

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