Journal of Reproductive Immunology
Volume 57, Issue 1 , Pages 143-150, October 2002

Indoleamine 2,3-dioxygenase, immunosuppression and pregnancy

Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA

Received 8 January 2002; received in revised form 5 April 2002; accepted 9 April 2002.

Abstract 

Pharmacologic inhibition of indoleamine 2,3-dioxygenase (IDO) activity during murine pregnancy results in maternal T-cell-mediated rejection of allogeneic but not syngeneic conceptuses. Increased risk of allogeneic pregnancy failure induced by exposure to IDO inhibitor is strongly correlated with maternal C3 deposition at the maternal–fetal interface. Here we review evidence that cells expressing IDO contribute to immunosuppression by inhibiting T-cell responses to tumor antigens and tissue allografts, as well as fetal tissues.

Keywords:  Indoleamine 2,3-dioxygenase, Immunosuppression, Pregnancy

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PII: S0165-0378(02)00040-2

Journal of Reproductive Immunology
Volume 57, Issue 1 , Pages 143-150, October 2002

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